Evidence verdicts

Which supplements and habits actually work

7 of 36 have strong consensus for: Fasting, Cold Exposure, Creatine, Sauna, Zone 2 Exercise, Magnesium, and Olive Oil. 5 of 36 have not enough evidence yet. Each verdict is worked out from every counted mention on the record.

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Strong consensus for 7Leaning for 21Mixed 1Conflicting 1Leaning against 1Strong consensus against 0Not enough evidence 5

positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.

Strong consensus for

7 topics

Leaning for

21 topics
Probiotics & Gut Health
supplements
Leaning for +14 30 sources: 15 positive, 14 partly, 1 negative

Probiotic supplements or fermented foods are worth taking.

30 sources: 15 positive, 14 partly, 1 negative

GLP-1 Agonists
supplements
Leaning for +2 18 sources: 6 positive, 9 partly, 3 negative

GLP-1 drugs are worth taking for people with obesity.

18 sources: 6 positive, 9 partly, 3 negative

Omega-3
supplements
Leaning for +1 17 sources: 7 positive, 10 partly

Omega-3 supplements are worth taking.

17 sources: 7 positive, 10 partly

Glutathione
supplements
Leaning for 15 sources: 2 positive, 11 partly, 2 negative

Glutathione supplements are worth taking.

15 sources: 2 positive, 11 partly, 2 negative

Caffeine
supplements
Leaning for 14 sources: 12 partly, 2 negative

Caffeine is worth using.

14 sources: 12 partly, 2 negative

Melatonin
supplements
Leaning for 13 sources: 3 positive, 9 partly, 1 negative

Melatonin is worth taking for sleep.

13 sources: 3 positive, 9 partly, 1 negative

Vitamin D
supplements
Leaning for 12 sources: 6 positive, 6 partly

Vitamin D supplements are worth taking.

12 sources: 6 positive, 6 partly

Vitamin B12
supplements
Leaning for 10 sources: 1 positive, 9 partly

Vitamin B12 supplements are worth taking.

10 sources: 1 positive, 9 partly

NAC
supplements
Leaning for 9 sources: 2 positive, 6 partly, 1 negative

NAC is worth taking.

9 sources: 2 positive, 6 partly, 1 negative

Electrolytes
supplements
Leaning for 8 sources: 3 positive, 5 partly

Electrolyte supplements are worth taking.

8 sources: 3 positive, 5 partly

Sleep Optimization
sleep
Leaning for 8 sources: 4 positive, 4 partly

Sleep is the most important pillar of health and longevity.

8 sources: 4 positive, 4 partly

Ashwagandha
supplements
Leaning for 6 sources: 3 positive, 3 partly

Ashwagandha is worth taking.

6 sources: 3 positive, 3 partly

Folate
supplements
Leaning for 6 sources: 6 partly

Folate supplements are worth taking.

6 sources: 6 partly

Garlic
supplements
Leaning for 6 sources: 6 partly

Garlic is worth taking for health.

6 sources: 6 partly

Glycine
supplements
Leaning for 6 sources: 3 positive, 3 partly

Glycine is worth taking.

6 sources: 3 positive, 3 partly

Zinc
supplements
Leaning for 6 sources: 2 positive, 4 partly

Zinc supplements are worth taking.

6 sources: 2 positive, 4 partly

CoQ10
supplements
Leaning for 5 sources: 2 positive, 2 partly, 1 negative

CoQ10 is worth taking.

5 sources: 2 positive, 2 partly, 1 negative

Vitamin C
supplements
Leaning for 5 sources: 1 positive, 3 partly, 1 neutral

Vitamin C supplements are worth taking.

5 sources: 1 positive, 3 partly, 1 neutral

Iron
supplements
Leaning for 4 sources: 1 positive, 3 partly

Iron supplements improve health only in people whose iron is low.

4 sources: 1 positive, 3 partly

Curcumin
supplements
Leaning for 3 sources: 2 positive, 1 partly

Curcumin is worth taking.

3 sources: 2 positive, 1 partly

Selenium
supplements
Leaning for 3 sources: 1 positive, 2 partly

Selenium supplements are worth taking.

3 sources: 1 positive, 2 partly

Mixed

1 topic

Conflicting

1 topic

Leaning against

1 topic

Not enough evidence

5 topics

Too few counted mentions to call either way. Each verdict updates as more mentions are counted.

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Cite as: Precis Consensus Matrix, 36 topics, precis.health/tools/consensus-matrix, updated 29 June 2026.

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How each verdict is worked out

Strong consensus
At least 4 counted mentions, at least 3 sources on the leading side, and no more than 15% on the other side. A mention that only partly agrees does not count toward it.
Leaning
One side leads, but short of strong consensus. A mention that partly agrees counts as half a vote.
Mixed
Neither side leads.
Conflicting
At least 25% of counted mentions are positive and at least 25% are negative.
Not enough evidence
Fewer than 3 counted mentions, all of them from one source, or too few that take a side.

Go deeper

How this is built: Built from 3,700+ hours of recorded interviews with 380+ researchers and doctors, plus 87,700+ research studies. Updated Oct 27, 2026. Each verdict is computed from every counted mention of the topic's main claim, never written by hand. Click a row to read the full report with its receipts.