Vitamin B12

Expert Positions

Andrew Huberman

Mentions in Context of Mental Health

Peter Attia

Includes in Personal Protocol

Rhonda Patrick

Recommends for MTHFR Variants

Bryan Johnson

No Direct Coverage

Mark Hyman

Strongly Recommends as Essential

The Verdict

3 of 5 experts actively recommend B12 supplementation, primarily for methylation support and brain health. Attia includes methylcobalamin in his personal protocol specifically to manage homocysteine levels. Hyman is the strongest advocate, linking B12 deficiency to depression, dementia, and neuropathy across dozens of videos. Patrick covers B12 in the context of genetics and MTHFR polymorphisms. Johnson and Huberman rarely address B12 directly — it appears only incidentally in broader discussions about mitochondrial health and mental health.