Melatonin

Expert Positions

Andrew Huberman

Cautions Against for Most Adults

Peter Attia

Last Resort After Sleep Hygiene

Rhonda Patrick

Values Endogenous Melatonin Over Supplements

Bryan Johnson

Takes Nightly in Blueprint Protocol

Mark Hyman

Recommends for Circadian Reset and Sleep

The Verdict

Melatonin is the most divisive supplement across our expert panel. Huberman explicitly cautions against supplemental melatonin for most adults, preferring behavioral tools and his magnesium-apigenin-theanine stack. Attia acknowledges melatonin's role in sleep regulation but treats it as a last resort after optimizing sleep hygiene. Patrick focuses on endogenous melatonin's metabolic and circadian functions rather than recommending supplements. Johnson takes melatonin nightly as part of his Blueprint protocol based on his team's evidence review. Hyman is the most favorable, recommending melatonin for circadian rhythm reset, sleep support, and even anti-inflammatory purposes.