Evidence report · Longevity and aging
NAD+ falls with age and matters for energy, DNA repair and sirtuins, so the case for precursors like NMN and NR sounds strong in theory. In practice, the ITP mouse trial of NR showed no lifespan gain, and human trials are small with mostly weak results. Exercise and fasting raise NAD naturally, and NMN may feed cancer growth in some settings.
Verdict
Mixed
NMN or NR supplements are worth taking.
10 sources: 2 positive, 4 partly, 4 negative
12 sources credited28 counted mentions29 episodes · 52 h26 checked quotesChecked against the tape 2026-03-19
Stance update (2025): NMN and NAD precursors have moved from 'unproven' to 'noise' on one evidence hierarchy (Peter Attia).
Each claim gets one verdict, worked out from every counted mention. One dot is one source: a researcher or a study. Tap a dot to see its receipt.
positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.
NMN or NR supplements are worth taking.
10 sources: 2 positive, 4 partly, 4 negative.
Researchers say
2 positive, 2 partly, 3 negative
Casey Means, on The Dr. Hyman Show, at 14:25
Positive Video · Opinion
No checked quote for this mention yet. The link opens the source at the moment it comes up.
Open the tape at 14:25 →Dr. David Sinclair, 4 mentions on this claim
Positive Video
on Huberman Lab, at 32:32 · positive
“Gave them NMN, and I think it was only six weeks later, they had offspring.”
on FoundMyFitness, at 36:40 · partly
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on FoundMyFitness, at 55:55 · partly
“NR did not increase endurance, but NMN did.”
on The Dr. Hyman Show, at 33:54 · partly
“the cell cells in the body take it up there's a transporter they get sucked up into cells and they immediately convert it into nad and we can see that there's a spike of nad produced after nmn after about two to three hours”
Mark Hyman, 3 mentions on this claim
Partly Video
on The Dr. Hyman Show, at 27:59 · positive
“I like certain things like nmn which is helped support adad production”
on The Dr. Hyman Show, at 06:38 · positive
“I take and amend about 900 milligrams a day which is a great dose of nmn”
on Huberman Lab, at 2:32:44 · partly
“it's an optimization tool because as you get older, NAD levels decline,”
Andrew Huberman, 2 mentions on this claim
Partly Video
on Huberman Lab, at 06:18 · partly
on Huberman Lab, at 08:42 · partly
“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
Iñigo San-Millán, 2 mentions on this claim
Negative Video
on The Drive, at 2:34:03 · negative
“taking n is that going to increase longevity I don't think so that's my opinion”
on The Drive, at 02:19 · negative
“taking nad is that going to increase longevity i don't think so that's my opinion”
Peter Attia, on The Drive, at 28:29
Negative Video · Opinion
Open the tape at 28:29 →“I kind of think this NAD stuff is noise at the moment”
Richard Miller, 2 mentions on this claim
Negative Video
on The Drive, at 1:51:47 · negative
“suggested that in our did not extend life span in our mice”
on The Drive, at 2:04:01 · negative
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Studies show
2 partly, 1 negative
3 cited on tape, not yet checked against the paper
David Sinclair, cited on The Dr. Hyman Show, at 25:47
Partly Study
Open the tape at 25:47 →“and they gave this old mice nmn and the mouse ran three kilometers and broke the treadmill”
McDermott, Northwestern, cited on FoundMyFitness, at 1:09:30
Partly Study
Open the tape at 1:09:30 →“found that the NR arm improved their six-minute walk test”
Josh Rabinowitz, cited on The Drive, at 00:48
Negative Study
Open the tape at 00:48 →“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching”
Casey Means, on The Dr. Hyman Show, at 14:25 Video · positive · Opinion
Dr. David Sinclair Video · positive · 4 mentions
on Huberman Lab, at 32:32 · positive · Their own research
“Gave them NMN, and I think it was only six weeks later, they had offspring.”
on FoundMyFitness, at 36:40 · partly · Opinion
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on FoundMyFitness, at 55:55 · partly · Their own research
“NR did not increase endurance, but NMN did.”
on The Dr. Hyman Show, at 33:54 · partly · Their own research
“the cell cells in the body take it up there's a transporter they get sucked up into cells and they immediately convert it into nad and we can see that there's a spike of nad produced after nmn after about two to three hours”
Mark Hyman Video · partly · 3 mentions
on The Dr. Hyman Show, at 27:59 · positive · Opinion
“I like certain things like nmn which is helped support adad production”
on The Dr. Hyman Show, at 06:38 · positive · Opinion
“I take and amend about 900 milligrams a day which is a great dose of nmn”
on Huberman Lab, at 2:32:44 · partly · Opinion
“it's an optimization tool because as you get older, NAD levels decline,”
Andrew Huberman Video · partly · 2 mentions
on Huberman Lab, at 06:18 · partly · Opinion
on Huberman Lab, at 08:42 · partly · Opinion
“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
David Sinclair, cited on The Dr. Hyman Show, at 25:47 Study · partly
“and they gave this old mice nmn and the mouse ran three kilometers and broke the treadmill”
McDermott, Northwestern, cited on FoundMyFitness, at 1:09:30 Study · partly
“found that the NR arm improved their six-minute walk test”
Iñigo San-Millán Video · negative · 2 mentions
on The Drive, at 2:34:03 · negative · Opinion
“taking n is that going to increase longevity I don't think so that's my opinion”
on The Drive, at 02:19 · negative · Opinion
“taking nad is that going to increase longevity i don't think so that's my opinion”
Peter Attia, on The Drive, at 28:29 Video · negative · Opinion
“I kind of think this NAD stuff is noise at the moment”
Richard Miller Video · negative · 2 mentions
on The Drive, at 1:51:47 · negative · Their own research
“suggested that in our did not extend life span in our mice”
on The Drive, at 2:04:01 · negative · Their own research
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Josh Rabinowitz, cited on The Drive, at 00:48 Study · negative
“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching”
Raising NAD+ with NMN or NR supplements slows aging.
10 sources: 1 positive, 3 partly, 6 negative.
Researchers say
2 partly, 5 negative
Dr. David Sinclair, 5 mentions on this claim
Partly Video
on FoundMyFitness, at 36:40 · partly
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on Huberman Lab, at 32:49 · partly
“You can rejuvenate the female reproductive system,”
on Lifespan, at 24:51 · partly
“We've done it once, and they do live longer on NMN.”
on The Drive, at 1:31:00 · partly
“we can still extend lifespan using what I know you were this is not gonna tell you we're using the nmn”
on Huberman Lab, at 1:38:37 · partly
“They became fertile again, which goes against biology, the textbook biology,”
Dr. Mark Hyman, on Huberman Lab, at 2:32:40
Partly Video · Opinion
Open the tape at 2:32:40 →“it's not going to make you live forever or cure every disease, but it's a it's an it's an optimization tool”
Iñigo San-Millán, 2 mentions on this claim
Negative Video
on The Drive, at 2:34:03 · negative
“now taking n is that going to increase longevity I don't think so”
on The Drive, at 02:19 · negative
“taking nad is that going to increase longevity i don't think so that's my opinion”
Eric Verdin, on The Drive, at 1:49:00
Negative Video · Opinion
Open the tape at 1:49:00 →“you keep pouring more NMN more NR inside of it you're just going to you're just going to accelerate you know the leak”
Peter Attia, on The Drive, at 28:29
Negative Video · Opinion
Open the tape at 28:29 →“I kind of think this NAD stuff is noise at the moment”
Richard Miller, 2 mentions on this claim
Negative Video
on The Drive, at 1:51:47 · negative
“suggested that in our did not extend life span in our mice”
on The Drive, at 2:04:01 · negative
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Andrew Huberman, 2 mentions on this claim
Negative Video
on Huberman Lab, at 06:18 · negative
on Huberman Lab, at 08:42 · negative
“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
Studies show
1 positive, 1 partly, 1 negative
3 cited on tape, not yet checked against the paper
David Sinclair, cited on The Dr. Hyman Show, at 25:47
Positive Study
Open the tape at 25:47 →“they gave this old mice nmn and the mouse ran three kilometers and broke the treadmill”
Shin Imai 2016, cited on FoundMyFitness, at 59:56
Partly Study
Open the tape at 59:56 →“what he showed was that over a year of treatment, pretty much all the parameters of health in these mice were improved.”
Josh Rabinowitz, cited on The Drive, at 00:48
Negative Study
Open the tape at 00:48 →“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching the companies”
David Sinclair, cited on The Dr. Hyman Show, at 25:47 Study · positive
“they gave this old mice nmn and the mouse ran three kilometers and broke the treadmill”
Dr. David Sinclair Video · partly · 5 mentions
on FoundMyFitness, at 36:40 · partly · Opinion
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on Huberman Lab, at 32:49 · partly · Their own research
“You can rejuvenate the female reproductive system,”
on Lifespan, at 24:51 · partly · Their own research
“We've done it once, and they do live longer on NMN.”
on The Drive, at 1:31:00 · partly · Their own research
“we can still extend lifespan using what I know you were this is not gonna tell you we're using the nmn”
on Huberman Lab, at 1:38:37 · partly · Their own research
“They became fertile again, which goes against biology, the textbook biology,”
Dr. Mark Hyman, on Huberman Lab, at 2:32:40 Video · partly · Opinion
“it's not going to make you live forever or cure every disease, but it's a it's an it's an optimization tool”
Shin Imai 2016, cited on FoundMyFitness, at 59:56 Study · partly
“what he showed was that over a year of treatment, pretty much all the parameters of health in these mice were improved.”
Iñigo San-Millán Video · negative · 2 mentions
on The Drive, at 2:34:03 · negative · Opinion
“now taking n is that going to increase longevity I don't think so”
on The Drive, at 02:19 · negative · Opinion
“taking nad is that going to increase longevity i don't think so that's my opinion”
Eric Verdin, on The Drive, at 1:49:00 Video · negative · Opinion
“you keep pouring more NMN more NR inside of it you're just going to you're just going to accelerate you know the leak”
Peter Attia, on The Drive, at 28:29 Video · negative · Opinion
“I kind of think this NAD stuff is noise at the moment”
Richard Miller Video · negative · 2 mentions
on The Drive, at 1:51:47 · negative · Their own research
“suggested that in our did not extend life span in our mice”
on The Drive, at 2:04:01 · negative · Their own research
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Andrew Huberman Video · negative · 2 mentions
on Huberman Lab, at 06:18 · negative · Opinion
on Huberman Lab, at 08:42 · negative · Opinion
“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
Josh Rabinowitz, cited on The Drive, at 00:48 Study · negative
“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching the companies”
7 more claims on dose, form and timing, each with its verdict and receipts, are in the full report.
6 risks to check before you start
Built from every credited researcher and cited study on each claim.
NMN or NR supplements are worth taking.
Casey Means, on The Dr. Hyman Show, at 14:25
Positive Video · Opinion
No checked quote for this mention yet. The link opens the source at the moment it comes up.
Open the tape at 14:25 →Dr. David Sinclair, 4 mentions on this claim
Positive Video
on Huberman Lab, at 32:32 · positive
“Gave them NMN, and I think it was only six weeks later, they had offspring.”
on FoundMyFitness, at 36:40 · partly
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on FoundMyFitness, at 55:55 · partly
“NR did not increase endurance, but NMN did.”
on The Dr. Hyman Show, at 33:54 · partly
“the cell cells in the body take it up there's a transporter they get sucked up into cells and they immediately convert it into nad and we can see that there's a spike of nad produced after nmn after about two to three hours”
Mark Hyman, 3 mentions on this claim
Partly Video
on The Dr. Hyman Show, at 27:59 · positive
“I like certain things like nmn which is helped support adad production”
on The Dr. Hyman Show, at 06:38 · positive
“I take and amend about 900 milligrams a day which is a great dose of nmn”
on Huberman Lab, at 2:32:44 · partly
“it's an optimization tool because as you get older, NAD levels decline,”
Andrew Huberman, 2 mentions on this claim
Partly Video
on Huberman Lab, at 06:18 · partly
on Huberman Lab, at 08:42 · partly
“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
David Sinclair, cited on The Dr. Hyman Show, at 25:47
Partly Study
Open the tape at 25:47 →“and they gave this old mice nmn and the mouse ran three kilometers and broke the treadmill”
McDermott, Northwestern, cited on FoundMyFitness, at 1:09:30
Partly Study
Open the tape at 1:09:30 →“found that the NR arm improved their six-minute walk test”
Iñigo San-Millán, 2 mentions on this claim
Negative Video
on The Drive, at 2:34:03 · negative
“taking n is that going to increase longevity I don't think so that's my opinion”
on The Drive, at 02:19 · negative
“taking nad is that going to increase longevity i don't think so that's my opinion”
Peter Attia, on The Drive, at 28:29
Negative Video · Opinion
Open the tape at 28:29 →“I kind of think this NAD stuff is noise at the moment”
Richard Miller, 2 mentions on this claim
Negative Video
on The Drive, at 1:51:47 · negative
“suggested that in our did not extend life span in our mice”
on The Drive, at 2:04:01 · negative
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Josh Rabinowitz, cited on The Drive, at 00:48
Negative Study
Open the tape at 00:48 →“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching”
Raising NAD+ with NMN or NR supplements slows aging.
David Sinclair, cited on The Dr. Hyman Show, at 25:47
Positive Study
Open the tape at 25:47 →“they gave this old mice nmn and the mouse ran three kilometers and broke the treadmill”
Dr. David Sinclair, 5 mentions on this claim
Partly Video
on FoundMyFitness, at 36:40 · partly
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on Huberman Lab, at 32:49 · partly
“You can rejuvenate the female reproductive system,”
on Lifespan, at 24:51 · partly
“We've done it once, and they do live longer on NMN.”
on The Drive, at 1:31:00 · partly
“we can still extend lifespan using what I know you were this is not gonna tell you we're using the nmn”
on Huberman Lab, at 1:38:37 · partly
“They became fertile again, which goes against biology, the textbook biology,”
Dr. Mark Hyman, on Huberman Lab, at 2:32:40
Partly Video · Opinion
Open the tape at 2:32:40 →“it's not going to make you live forever or cure every disease, but it's a it's an it's an optimization tool”
Shin Imai 2016, cited on FoundMyFitness, at 59:56
Partly Study
Open the tape at 59:56 →“what he showed was that over a year of treatment, pretty much all the parameters of health in these mice were improved.”
Iñigo San-Millán, 2 mentions on this claim
Negative Video
on The Drive, at 2:34:03 · negative
“now taking n is that going to increase longevity I don't think so”
on The Drive, at 02:19 · negative
“taking nad is that going to increase longevity i don't think so that's my opinion”
Eric Verdin, on The Drive, at 1:49:00
Negative Video · Opinion
Open the tape at 1:49:00 →“you keep pouring more NMN more NR inside of it you're just going to you're just going to accelerate you know the leak”
Peter Attia, on The Drive, at 28:29
Negative Video · Opinion
Open the tape at 28:29 →“I kind of think this NAD stuff is noise at the moment”
Richard Miller, 2 mentions on this claim
Negative Video
on The Drive, at 1:51:47 · negative
“suggested that in our did not extend life span in our mice”
on The Drive, at 2:04:01 · negative
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Andrew Huberman, 2 mentions on this claim
Negative Video
on Huberman Lab, at 06:18 · negative
on Huberman Lab, at 08:42 · negative
“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
Josh Rabinowitz, cited on The Drive, at 00:48
Negative Study
Open the tape at 00:48 →“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching the companies”
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This report on NMN & NAD+ draws on 29 videos (52 hours analyzed) out of 3,700+ hours of recorded interviews with 370+ researchers and doctors, plus 18,100+ research studies. Every mention of a claim gets a stance, and the verdict is worked out from all of them, never written by hand.
The full report adds 8 key findings and the dose and protocol. It also has the verdict on every claim, a receipt for each mention, the risks to check, and what combines with it.
Get dosages, timing and the verdict on every claim with its receipts for NMN & NAD+.