Metformin

Expert Positions

Andrew Huberman

Explicitly Avoids for Longevity

Peter Attia

Shifted from Cautious to Skeptical

Rhonda Patrick

Minimal Direct Coverage

Bryan Johnson

Uses in Blueprint Protocol

Mark Hyman

Prefers Lifestyle Over Metformin

The Verdict

Metformin is the most debated longevity drug among the 5 experts. Attia has extensively covered it across 27+ videos but shifted from cautious optimism to skepticism, concluding it may be a mitochondrial toxin for healthy individuals. Huberman explicitly avoids it for longevity. Hyman acknowledges it as the safest diabetes drug but favors lifestyle interventions over pharmacological approaches. Patrick has minimal coverage. Johnson includes metformin in his Blueprint protocol but is discussed only via Hyman's channel.