Evidence report · Longevity and aging

Rapamycin

Rapamycin has the strongest animal lifespan data of any drug, but human evidence for longevity is close to absent. It is a prescription immunosuppressant, low-dose weekly use is experimental, and no biomarker guides the dose. Reported side effects include mouth sores, slow wound healing, higher cholesterol and a faster resting heart rate.

Verdict

Not enough evidence

Low-dose rapamycin slows aging in healthy people.

2 sources: 2 negative

2 sources: 2 negative

4 sources credited5 counted mentions28 episodes · 38 h5 checked quotesChecked against the tape 2026-03-23

Does it work?

Each claim gets one verdict, worked out from every counted mention. One dot is one source: a researcher or a study. Tap a dot to see its receipt.

positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.

  1. Not enough evidence

    Low-dose rapamycin slows aging in healthy people.

    2 sources: 2 negative. Fewer than 3 sources so far.

    Researchers say

    1 negative

    Studies show

    1 negative

    1 paper we read

    44 more not counted · see why
    We could not tell what position it takes on this claim. 16
    We could not confirm who is speaking. 10
    A host's remark inside an interview. 7
    We could not tell where the evidence comes from. 5
    The study is not yet read in full. 3
    The study cited could not be identified. 2
    No quote from the tape on record yet. 1
    Show the receipts from 2 sources

    1. Bryan Johnson, on Bryan Johnson's channel, at 00:12 Video · negative · Opinion

      “Turns out I was actually accelerating my speed of aging.”

    2. Controlled trial, Exp Gerontol, 2018, PMID 29408453 Study · negative

      Similarly, no changes were noted in any other clinical laboratory, cognitive, physical performance, or self-perceived health status measure over the study period.

2 more claims on dose, form and timing, each with its verdict and receipts, are in the full report.

How much, which type, and when?

Free with an account ↓
Dose
Form
Timing
Evidence
Verdict
Not enough evidence · 2 sources: 2 negative

Is it safe for me?

8 risks to check before you start

  1. Rapamycin suppresses the immune system at transplant doses; even at lower longevity doses, immunity may be weakened and infection risk higher.
  2. Reported side effects include mouth sores (aphthous ulcers), slow wound healing, higher cholesterol and a faster resting heart rate (Bryan Johnson).
  3. Inhibiting mTORC2 may cause insulin resistance and poorer glucose control, the opposite of what a longevity drug should do.
  4. A pre-print suggested rapamycin may speed biological aging in humans, cutting against the animal data that sparked longevity interest.
  5. Rapamycin inhibits mTOR, which muscle protein synthesis needs, so long-term use may impair muscle upkeep, a problem for older people already at risk of sarcopenia.
  6. No biomarkers exist to guide longevity dosing in humans (Matt Kaeberlein, on The Drive).
  7. Long-term safety data for low-dose intermittent rapamycin in healthy people are essentially absent; what exists comes from transplant patients on much higher continuous doses.
  8. Rapamycin has serious drug interactions, especially with immunosuppressants, some antibiotics and antifungals. Never use it without medical supervision.

Why do the sources disagree?

Built from every credited researcher and cited study on each claim.

On the claims above, no counted source takes a different side yet.

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About This Analysis

This report on Rapamycin draws on 28 videos (38 hours analyzed) out of 3,700+ hours of recorded interviews with 380 researchers and doctors, plus 48,500+ research studies. Every mention of a claim gets a stance, and the verdict is worked out from all of them, never written by hand.

The full report adds 8 key findings and the dose and protocol. It also has the verdict on every claim, a receipt for each mention, the risks to check, and what combines with it.

Frequently Asked Questions

What does the evidence say about rapamycin?
Rapamycin has the strongest animal lifespan data of any drug, but human evidence for longevity is close to absent. It is a prescription immunosuppressant, low-dose weekly use is experimental, and no biomarker guides the dose.
How strong is the evidence on rapamycin?
The verdict on “Low-dose rapamycin slows aging in healthy people” is Not enough evidence. 2 sources: 2 negative.

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Get dosages, timing and the verdict on every claim with its receipts for Rapamycin.