Mark Hyman's Supplement Stack

Hyman is one of the strongest advocates for omega-3 supplementation, listing it alongside vitamin D and magnesium as one of the foundational supplements everyone needs. He discusses omega-3 across dozens of videos covering inflammation, heart disease,...

“The most prevalent deficiencies include iron, vitamin D, magnesium, and omega-3s — these are the big ones.” ▶ source (01:38)

Hyman discusses creatine across 10 videos, recently adding it to his list of six essential daily supplements alongside a multivitamin, omega-3s, polyphenols, vitamin D, magnesium, and probiotics. He recommends creatine for supporting muscle mass, insulin...

“Covers the benefits of probiotics for gut microbiome health and the use of creatine to support muscle mass, insulin sensitivity, and cognitive function as we age.” ▶ source (19:28)

Hyman is the most prolific advocate for gut health and probiotics across all five experts, discussing it as a central theme in dozens of videos. He views the gut as the epicenter of health and disease, connecting dysbiosis to conditions ranging from...

“Dr. Hyman outlines the 5R program — Remove, Replace, Re-inoculate, Repair, and Rebalance — as a comprehensive framework for resetting the gut and addressing root causes of disease.” ▶ source (13:58)

Hyman is the most prolific expert on zinc, mentioning it across dozens of videos spanning immune resilience, gut health, brain function, fertility, skin conditions, thyroid support, detoxification, and mental health. He identifies zinc as one of the most...

“Analysis of NHANES data reveals that over 90% of Americans are deficient in key nutrients like omega-3s, magnesium, and zinc, which are essential for cellular enzyme function.” ▶ source (01:42)

Hyman is one of the two strongest advocates for magnesium, discussing it across at least 4 videos with dozens of mentions. He calls it one of the foundational supplements 'everybody needs,' citing its role in over 600 enzyme reactions and subclinical...

“The most prevalent deficiencies include iron, vitamin D, magnesium, and omega-3s — these are the big ones.” ▶ source (02:15)

Hyman discusses glycine across multiple videos, primarily in the context of sleep optimization and glutathione production. He recommends glycine alongside magnesium for relaxing the nervous system and improving sleep quality. In his glutathione video, he...

“Supplements like magnesium and glycine can help relax the nervous system and muscles. Melatonin can assist in resetting circadian rhythms, and herbs like ashwagandha can help...” ▶ source (03:37)

Hyman is the most prolific source on iron across all five experts, discussing it across at least 15 videos in contexts ranging from daily supplementation to fertility, hair loss, mental health, sleep, autoimmune disease, and detoxification. He includes iron...

“Discusses the importance of iron bisglycinate for those with low ferritin levels, which are often overlooked in standard lab ranges.” ▶ source (03:36)

Hyman is one of the two strongest advocates for vitamin D supplementation, discussing it across at least 123 videos. He calls it one of the essential supplements 'everybody needs' and has multiple dedicated videos on the topic. He recommends vitamin D3 (not...

“Optimizing vitamin D can be achieved through diet, sensible sun exposure, or supplementation. While fortified foods exist, they often use the less effective D2 form....” ▶ source (10:07)

Hyman discusses ashwagandha across 6 videos, consistently recommending it as an adaptogenic herb for adrenal dysfunction, stress resilience, and cortisol management. He pairs it with rhodiola, Siberian ginseng, magnesium, and methylated B vitamins for...

“Ashwagandha listed as adaptogenic herb alongside Siberian ginseng and rhodiola for adrenal support. Recommended with multivitamin, Vitamin C, zinc, B-complex.” ▶ source (03:30)

Hyman provides the most extensive coverage of astaxanthin among the five experts. His dedicated interview with David Watumull covers the full spectrum of astaxanthin's mechanisms and benefits. He explains that astaxanthin originates in microalgae as a...

“Astaxanthin is presented as a potent plant compound found in algae and oceans, offering protective benefits. Research, including that from the NIH, explores natural and...” ▶ source (01:15)

Hyman is the most prolific source on CoQ10, discussing it across 23 videos. He has a dedicated episode covering CoQ10's mechanism of action in ATP production, statin-induced depletion, clinical benefits for heart failure and migraines, metabolic health...

“Coenzyme Q10 is a vital molecule that helps convert food and oxygen into ATP, the energy currency of the body, within the mitochondria.” ▶ source (00:00)

Hyman takes a food-first approach to collagen, advocating for bone broth as a gut-healing food rich in connective tissue. He hosted Marco Canora for a dedicated bone broth episode discussing its role in gut health. For microbiome repair, he uses collagen...

“Marco details the health benefits of bone broth, its role in gut health, and how to create a nutrient-dense, flavorful product using connective tissues.” ▶ source (12:48)

Hyman is the most prolific advocate for curcumin across all five experts, discussing it in over 20 videos spanning inflammation, immune support, gut health, joint health, brain health, autoimmune disease, and longevity. He recommends curcumin as a...

“A discussion on the potential of fecal microbiota transplants, probiotics, and anti-inflammatory supplements like curcumin as complementary tools for managing IBD symptoms.” ▶ source (05:48)

Hyman addresses electrolytes from both a clinical and public health perspective. He warns that proper hydration requires electrolytes for intracellular absorption, and that over-drinking plain water can dangerously dilute blood minerals. He recommends...

“Proper hydration requires electrolytes to ensure intracellular absorption. Over-drinking plain water can lead to dangerous dilution of blood minerals.” ▶ source (15:17)

Hyman is the most prolific garlic advocate among the five experts, discussing it across at least 17 videos in multiple health contexts. His primary framing positions garlic as a sulfur-rich allium vegetable essential for boosting glutathione — the body's...

“To naturally increase glutathione, consume sulfur-rich foods including the allium family (garlic, onions, leeks) and cruciferous vegetables (broccoli, kale, cabbage).” ▶ source (01:49)

Hyman is the strongest advocate for NAC across all five experts, discussing it in at least 24 videos. He consistently positions NAC as the key precursor to glutathione — which he calls 'the body's most important molecule' for detoxification, immune...

“Glutathione levels can be increased through sulfur-rich foods, bioactive whey protein, regular exercise, and targeted supplementation including NAC, alpha-lipoic acid,...” ▶ source (03:58)

Hyman is the most prolific and passionate advocate for B12 supplementation among the five experts, discussing it across more than 25 videos in contexts ranging from brain health and depression to gut health, fertility, and aging. He frames B12 as one of the...

“Dr. Hedaya recounts a detailed case of a patient suffering from panic attacks, initially treated with conventional therapies like CBT and medication, which proved ineffective....” ▶ source (02:30)

Hyman discusses berberine across 4 videos in two distinct contexts: as an AMPK-activating longevity compound and as an herbal antimicrobial for gut health. In his anti-aging mechanisms video, he highlights berberine alongside quercetin, resveratrol, and...

“Specific compounds such as quercetin, resveratrol, berberine, and lipoic acid can activate AMPK and downstream pathways like FOXO and PGC1 to combat inflammation and oxidative...” ▶ source (01:13)

Hyman is the dominant voice on glutathione across all five experts, discussing it in at least 29 videos. He calls glutathione 'the body's most important molecule' and 'the master antioxidant,' positioning it as essential for detoxification, immune function,...

“Glutathione levels can be increased through sulfur-rich foods, bioactive whey protein, regular exercise, and targeted supplementation including NAC, alpha-lipoic acid,...” ▶ source (03:58)

Hyman is by far the most prolific advocate for vitamin C supplementation, mentioning it across at least 36 videos in wide-ranging contexts. He recommends vitamin C alongside zinc for immune support and white blood cell production, pairs it with vitamin D...

“The video emphasizes the importance of Vitamin C and Zinc for immune function. Vitamin C supports white blood cell production, while Zinc helps stop viral replication. Both can...” ▶ source (06:00)

Hyman is the strongest K2 advocate, consistently pairing D3 with K2 across 4 videos. In his Ultimate Supplement Guide, D3+K2 is one of his top 3 foundational supplements alongside a multivitamin and fish oil. He recommends D3 'ideally with K2 and magnesium'...

“Dr. Hyman recommends a core foundation of a high-quality multivitamin, fish oil, and vitamin D3 with K2 for optimal health.” ▶ source (13:06)

Hyman is the dominant voice on selenium, discussing it across at least 19 videos spanning thyroid health, immune function, glutathione production, detoxification, male fertility, and autoimmune disease management. He consistently identifies selenium as a...

“Thyroid issues are frequently driven by environmental toxins, chronic stress, nutrient deficiencies (like selenium and iodine), and gluten sensitivity, rather than just genetics.” ▶ source (04:04)

Hyman is the most prolific and passionate advocate for folate supplementation among the five experts, discussing it across at least 18 videos. He consistently recommends methylated folate (5-MTHF) as a foundational supplement for brain health, fertility,...

“Vitamin D is vital for immune and cognitive function, with many people requiring supplementation to reach optimal levels of 50-75 ng/dL. Additionally, methylating nutrients like...” ▶ source (03:49)

Hyman is the most enthusiastic proponent of supplemental melatonin, recommending it across at least 10 videos for a wide range of purposes: circadian rhythm reset, sleep support, jet lag management, anti-inflammatory immune support, acid reflux relief,...

“Melatonin can assist in resetting circadian rhythms, and herbs like ashwagandha can help manage cortisol. Creating a sleep-conducive environment with blackout shades and...” ▶ source (03:37)

Hyman discusses sulforaphane across at least 13 videos, consistently framing it within his food-as-medicine and functional medicine philosophy. He positions sulforaphane and cruciferous vegetables as essential for Nrf2 pathway activation, liver...

“Cruciferous vegetables like broccoli, kale, and arugula are essential for liver health because they contain compounds that support both phases of detoxification. Specifically,...” ▶ source (00:10)

Hyman is the most enthusiastic advocate for NAD precursors among our five experts. Across multiple videos and guest interviews, he frames NAD as essential for mitochondrial energy production, DNA repair, sirtuin activation, and glutathione synthesis. He...

“While NAD itself cannot easily cross cell membranes, precursors like NMN and NR can. NMN is considered superior because the body possesses a specific shuttle mechanism to...” ▶ source (15:35)