Ask David Sinclair

Harvard geneticist and author of Lifespan.

24 episodes, 30.1 hours of tape. Every answer comes from those episodes, with the minute it was said.

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Popular questions

Answered from the tape, with the episode and the minute. Where a guest was in the room, it says so.

  1. How much NMN does David Sinclair take?

    “I'm always happy to tell you what I do and what my father does, my 82-year-old father, we take a gram of NMN every day.”

    ▶ 1:02:45 · The Biology of Slowing & Reversing Aging | Dr. David Sinclair · Andrew Huberman's channel

  2. When does Sinclair take his NMN?

    “I take 1 g of NMN every every morning along with my resveratrol”

    ▶ 65:20 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4 · David Sinclair's channel

  3. How much metformin does Sinclair take, and when?

    “Uh I take 800 mg at night”

    ▶ 66:15 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4 · David Sinclair's channel

  4. What is Sinclair's senolytic maintenance dose?

    “These are high doses. They're typically 2 g taken one day a week for a matter of months. I'm myself I'm on a maintenance dose. I take about half a gram of each every day”

    ▶ 68:05 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4 · David Sinclair's channel

  5. What is in David Sinclair's morning stack?

    “Resveratrol, 1 g. In the morning with yogurt or olive oil. NMN as well. A gram, yeah. Fisetin and quercetin. Half a gram in the yogurt. Spermidine. Definitely spermidine, yeah, in the morning, about a gram.”

    ▶ 68:18 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4 · David Sinclair's channel

  6. What resveratrol dose range does Sinclair cite?

    “The minimum that I've seen is 250 milligrams a day and some people take a thousand or two thousand milligrams a day”

    ▶ 38:42 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4 · David Sinclair's channel

The episodes

The chat searches all of them.

Episode Show Length Aired
Why We Age | Lifespan with Dr. David Sinclair - S2, Ep. 7 David Sinclair 30 min Sep 2026
Why Exercise Slows Aging | Lifespan with Dr. David Sinclair - S2, Ep. 6 David Sinclair 71 min Aug 2026
How to Exercise to Live Longer | Lifespan with Dr. David Sinclair - S2, Ep. 5 David Sinclair 69 min Aug 2026
Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4 David Sinclair 72 min Jul 2026
What to Eat & When to Eat for Longevity: New Science | Lifespan with Dr. David Sinclair - S2, Ep. 3 David Sinclair 68 min Jul 2026
Fasting as a Path to Longevity: The Facts | Lifespan with Dr. David Sinclair - S2, Ep. 2 David Sinclair 75 min Jun 2026
The Longevity Revolution Is Here | Lifespan with Dr. David Sinclair - S2, Ep. 1 David Sinclair 66 min Jun 2026
The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind Episode David Sinclair 76 min May 2026
What To Do For Longevity | Lifespan with Dr. David Sinclair Rewind Episode David Sinclair 59 min May 2026
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair Andrew Huberman 34 min Oct 2025
Biotracking, Age Reversal & Other Advanced Health Technologies | Lifespan with Dr. David Sinclair #8 David Sinclair 69 min Feb 2022
The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7 David Sinclair 62 min Feb 2022
REVERSE AGING: What To Eat & When To Eat To INCREASE LONGEVITY | Dr. David Sinclair Mark Hyman 87 min Feb 2022
The Science of Looking Younger, Longer | Lifespan with Dr. David Sinclair #6 David Sinclair 70 min Feb 2022
Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity | Lifespan w Dr. David Sinclair #5 David Sinclair 59 min Feb 2022
NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4 David Sinclair 70 min Jan 2022
Exercise, Heat, Cold & Other Stressors for Longevity | Lifespan with Dr. David Sinclair #3 David Sinclair 71 min Jan 2022
What to Eat & When to Eat for Longevity | Lifespan with Dr. David Sinclair #2 David Sinclair 68 min Jan 2022
The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1 David Sinclair 62 min Jan 2022
The Biology of Slowing & Reversing Aging | Dr. David Sinclair Andrew Huberman 130 min Dec 2021
REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair Rangan Chatterjee 125 min Oct 2021
#70–David Sinclair, PhD: How cellular reprogramming could slow our aging clock, & the latest on NAD Peter Attia 130 min Jan 2020
#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging Peter Attia 101 min Jan 2020
Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More Rhonda Patrick 72 min Nov 2019

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