Best Supplements for Energy

All 5 experts actively recommend creatine — and the consensus has expanded well beyond muscle. Huberman, Attia, and Patrick each feature dedicated deep dives on creatine as brain fuel for cognition under stress, sleep deprivation, and aging — not just strength and hypertrophy. Johnson includes it in his Blueprint stack; Hyman names it one of six essential daily supplements for muscle mass, insulin sensitivity, and brain health as we age. The most common worry — elevated creatinine on bloodwork — is a harmless artifact of muscle metabolism, not kidney damage.

All 5 experts acknowledge iron as essential, but the consensus is unusually nuanced: test first, supplement only if deficient, and monitor carefully. Attia provides the deepest biochemical coverage with a dedicated iron episode. Hyman includes iron bisglycinate in his personal daily stack and flags it as one of the most prevalent deficiencies. Johnson actively supplements heme iron for borderline levels. Patrick highlights excess iron as an aging accelerant. The universal theme is that iron is a double-edged sword — both deficiency and overload are dangerous.

CoQ10 receives strong endorsement from Hyman, who has a dedicated deep dive and recommends it across 20+ videos as a cornerstone of mitochondrial support. Huberman mentions CoQ10 as a beneficial fertility supplement. Johnson includes CoQ10 in his Blueprint oral health protocol. Attia and Patrick do not specifically discuss CoQ10 supplementation in their analyzed content, though both emphasize mitochondrial health through other interventions.

3 of 5 experts actively recommend B12 supplementation, primarily for methylation support and brain health. Attia includes methylcobalamin in his personal protocol specifically to manage homocysteine levels. Hyman is the strongest advocate, linking B12 deficiency to depression, dementia, and neuropathy across dozens of videos. Patrick covers B12 in the context of genetics and MTHFR polymorphisms. Johnson and Huberman rarely address B12 directly — it appears only incidentally in broader discussions about mitochondrial health and mental health.