Goal-Based Guide
No supplement drives weight loss on its own. Omega-3 and probiotics have support for general health, while caffeine and berberine, the so-called natural Ozempic, have far weaker support for fat loss. Here's what each one does.
No supplement replaces a caloric deficit and exercise. But these compounds have some evidence for supporting fat loss when combined with lifestyle interventions.
Ranked by the verdict on whether each supplement works, worked out from every counted mention. Each dot is one source: a researcher or a study.
positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.
Probiotic supplements or fermented foods are worth taking.
30 sources: 15 positive, 14 partly, 1 negative
Omega-3 supplements are worth taking.
17 sources: 7 positive, 10 partly
Caffeine is worth using.
14 sources: 12 partly, 2 negative
Berberine is worth taking.
2 sources: 2 partly
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These are not magic pills. They support metabolic health alongside diet and exercise:
This page shows you which supplements researchers agree on for weight loss. A free account opens the dose, form and timing for each supplement, with the interactions to watch. Pro adds chat answers drawn from 3,700+ hours of recorded interviews with 380 researchers and doctors, plus 48,500+ research studies, each one cited.
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