Consensus Report
Vitamin B12
Moderate Consensus
out of 5
Based on 182 videos (134 hours analyzed) across 5 experts · Updated 2026-03-23
Expert Positions
The Verdict
3 of 5 experts actively recommend B12 supplementation, primarily for methylation support and brain health. Attia includes methylcobalamin in his personal protocol specifically to manage homocysteine levels. Hyman is the strongest advocate, linking B12 deficiency to depression, dementia, and neuropathy across dozens of videos. Patrick covers B12 in the context of genetics and MTHFR polymorphisms. Johnson and Huberman rarely address B12 directly — it appears only incidentally in broader discussions about mitochondrial health and mental health.
Where They Disagree
Depth of coverage varies dramatically: Hyman treats B12 as a foundational supplement that 'everybody needs' to test for, while Huberman and Johnson barely mention it. This reflects differing clinical vs. biohacking perspectives rather than a scientific disagreement.
Attia's approach is strictly biomarker-driven — he supplements B12 only to manage homocysteine as a cardiovascular risk metric, not as a general health recommendation. Hyman takes a broader view, recommending B12 for brain health, energy, mood, and methylation support.
+ 2 more disagreements in the full report
About This Analysis
This consensus report on Vitamin B12 is based on 182 videos (134 hours analyzed) from five longevity experts: Andrew Huberman, Peter Attia, Rhonda Patrick, Bryan Johnson, and Mark Hyman. Each expert's position was independently analyzed from their published video content, including lectures, podcast episodes, and Q&A sessions with 1,000+ guest scientists.
The full report includes 7 key findings, dosage and protocol details, expert deep dives with direct video citations and timestamps, risk considerations, and related supplement synergies.
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