Goal-Based Guide

Best Supplements for Anxiety

Anxiety management is one of the most common reasons people reach for supplements. These are the compounds with the strongest expert endorsement for stress and cortisol reduction.

This content is based on expert analysis of publicly available videos, not medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement.

Top Supplements for Anxiety

The Stress & Anxiety Stack

Evidence-based cortisol management from expert protocols:

  • Ashwagandha — 300mg twice daily for cortisol reduction; cycle off after 30 days (Huberman)
  • Magnesium glycinate — 300-400mg in the evening for GABA activity and muscle relaxation
  • L-Theanine — 100-200mg for calming without sedation (Huberman, Patrick)
  • Apigenin — 50mg in the evening alongside ashwagandha for cortisol (Huberman)

Common Mistakes

Taking ashwagandha continuously without cycling. Huberman is the only expert to specify: 30 days on, then off.

Using melatonin for anxiety-related sleep issues. Huberman prefers behavioral tools and his magnesium-apigenin-theanine stack.

Not monitoring thyroid and hormonal markers when taking ashwagandha. It can affect testosterone and thyroid function.

Ignoring root-cause interventions: sleep, exercise, and stress management practices.

Know what to take. Now learn exactly how.

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