Best Supplements for Skin Health

All 5 experts actively recommend omega-3 supplementation, making this one of the strongest consensus topics. Patrick and Attia provide the deepest mechanistic coverage, Huberman recommends 1-3g EPA for mood and cognition, Hyman lists omega-3 as a foundational supplement everyone needs, and Johnson includes omega-3 sources in his Blueprint diet.

All 5 experts mention astaxanthin positively, but with varying depth and enthusiasm. Hyman provides the most extensive coverage through a dedicated interview on astaxanthin's longevity mechanisms. Patrick highlights its role as a potent antioxidant in krill oil and salmon roe that activates the FOXO3 longevity gene. Attia discusses ITP data showing a 10% lifespan increase in male mice but notes more dose-response research is needed. Huberman recommends it specifically for eye health and ocular blood flow. Johnson includes astaxanthin in his Blueprint supplement stack without detailed commentary.

4 of 5 experts support collagen for skin and connective tissue health, but Attia is notably skeptical — citing research showing collagen does not outperform whey protein for connective tissue synthesis. Johnson is the strongest advocate, taking collagen peptides daily in his Blueprint protocol. Huberman recommends it specifically for skin, not muscle. All experts agree collagen is inferior to whey for muscle building.

3 of 5 experts view vitamin C as broadly useful — Patrick has a dedicated deep-dive covering oral vs. IV forms, Hyman recommends it across dozens of videos for immune support, stress, and detox, and Johnson includes it in his daily protocol alongside iron. Huberman notes that high-dose vitamin C has shown limited effectiveness for colds. Attia is the most skeptical, arguing that mega-dosing offers no benefit beyond correcting deficiency and that oral absorption is severely limited.