Best Supplements for Focus

All 5 experts actively recommend omega-3 supplementation, making this one of the strongest consensus topics. Patrick and Attia provide the deepest mechanistic coverage, Huberman recommends 1-3g EPA for mood and cognition, Hyman lists omega-3 as a foundational supplement everyone needs, and Johnson includes omega-3 sources in his Blueprint diet.

All 5 experts actively recommend creatine — and the consensus has expanded well beyond muscle. Huberman, Attia, and Patrick each feature dedicated deep dives on creatine as brain fuel for cognition under stress, sleep deprivation, and aging — not just strength and hypertrophy. Johnson includes it in his Blueprint stack; Hyman names it one of six essential daily supplements for muscle mass, insulin sensitivity, and brain health as we age. The most common worry — elevated creatinine on bloodwork — is a harmless artifact of muscle metabolism, not kidney damage.

All 5 experts acknowledge caffeine as a potent performance enhancer and cognitive tool, but they diverge significantly on whether it belongs in a longevity protocol. Huberman and Patrick are the strongest advocates, each dedicating deep coverage to caffeine's mechanisms, dosing, and health benefits. Attia views caffeine as a reliable ergogenic aid but emphasizes strict timing to protect sleep. Johnson actively avoids caffeine entirely as part of his Blueprint protocol. Hyman frames caffeine as a crutch that masks underlying health issues and recommends elimination during reset protocols.