Timing Protocol
When to Take Rapamycin — Expert Timing Protocols
Expert-analyzed timing recommendations for rapamycin based on what 5 longevity researchers say about when, how, and what to take it with.
Quick Timing Guide
Intermittent dosing (typically once weekly) is the approach discussed for longevity use, as opposed to the daily high-dose regimen used in transplant medicine. The goal is to preferentially inhibit mTORC1 while allowing mTORC2 recovery between doses (Attia).
Moderate Consensus
on Rapamycin overall
Full Protocol
Timing
Intermittent dosing (typically once weekly) is the approach discussed for longevity use, as opposed to the daily high-dose regimen used in transplant medicine. The goal is to preferentially inhibit mTORC1 while allowing mTORC2 recovery between doses (Attia).
Dosage
No consensus among the 5 experts. Attia uses low-dose intermittent protocols in clinical practice but emphasizes there are no clear biomarkers to guide optimal dosing. Common off-label longevity dosing discussed in the literature is 3-6mg once weekly, but this is not standardized. Johnson tried multiple dosing protocols before discontinuing entirely.
Form
Sirolimus (rapamycin) is a prescription pharmaceutical, not an over-the-counter supplement. It requires a physician's prescription and monitoring. FDA-approved for organ transplant rejection prevention.
Notes
Rapamycin is a prescription drug, not a supplement — it requires medical supervision and regular blood monitoring. Attia emphasizes thorough discussion of risks and uncertainties with patients before prescribing. Johnson's experience demonstrates that even with extensive medical oversight, side effects can outweigh perceived benefits. This is NOT a self-medication candidate.
What Each Expert Says About Timing
Huberman discusses rapamycin across 2 videos with a clear personal stance: he avoids it. In his dedicated longevity supplements AMA, he explicitly states he avoids metformin, berberine, and rapamyc...
Attia provides the most extensive rapamycin coverage of any expert, discussing it across approximately 15 videos. He considers rapamycin a potential 'gold standard' for small molecule interventions...
Rhonda Patrick discusses the mTOR pathway extensively across 4 videos but does not directly cover rapamycin as a longevity supplement. Her mTOR content focuses on dietary modulation — how amino aci...
Bryan Johnson provides the most dramatic rapamycin coverage among the 5 experts — a detailed personal account of experimentation and failure. Across 2 dedicated videos and a guest appearance on Hym...
Hyman discusses rapamycin and the mTOR pathway across multiple videos, but his coverage is primarily educational rather than prescriptive. He frames mTOR as one of four key 'longevity switches' (al...
Important Notes
Rapamycin is a prescription drug, not a supplement — it requires medical supervision and regular blood monitoring. Attia emphasizes thorough discussion of risks and uncertainties with patients before prescribing. Johnson's experience demonstrates that even with extensive medical oversight, side effects can outweigh perceived benefits. This is NOT a self-medication candidate.
Where Experts Disagree
- Attia cautiously prescribes rapamycin to patients and calls it a potential 'gold standard' geroprotective molecule, while Huberman explicitly avoids it and cites insufficient human evidence for longevity.
- Johnson experimented with rapamycin extensively and concluded it accelerated his aging, while Attia continues to view it as one of the most promising longevity interventions when dosed correctly.
- Attia focuses on the potential of low-dose intermittent rapamycin to selectively inhibit mTORC1, while Johnson's experience suggests that in practice, separating mTORC1 and mTORC2 effects is extremely difficult.
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