Timing Protocol

When to Take Rapamycin

What researchers say about when, how and with what to take rapamycin, and how strong the evidence is.

The verdict on Rapamycin overall

Not enough evidence

Low-dose rapamycin slows aging in healthy people.

2 sources: 2 negative

2 sources: 2 negative

Based on what researchers say in publicly available videos, not medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement.

Short answer

Intermittent dosing, usually once weekly, is the approach for longevity, unlike the daily high-dose regimen in transplant medicine. The aim is to inhibit mTORC1 while letting mTORC2 recover between doses (Brian Kennedy, on The Drive).

Full Protocol

Timing
Intermittent dosing, usually once weekly, is the approach for longevity, unlike the daily high-dose regimen in transplant medicine. The aim is to inhibit mTORC1 while letting mTORC2 recover between doses (Brian Kennedy, on The Drive).
Dosage
There is no agreed dose. Low-dose intermittent use is the clinical approach, with no clear biomarkers to guide it (Matt Kaeberlein, on The Drive). Off-label longevity dosing in the literature is commonly 3-6mg once weekly, but it is not standardized. Several protocols were tried before stopping entirely in one self-experiment (Bryan Johnson).
Form
Sirolimus (rapamycin) is a prescription drug, not an over-the-counter supplement. It needs a doctor's prescription and monitoring. It is FDA-approved to prevent organ transplant rejection.
Notes
Rapamycin is a prescription drug, not a supplement, and needs medical supervision and regular blood monitoring. Discuss its risks and uncertainties fully with your doctor first (Brian Kennedy, on The Drive). Even with close medical oversight, side effects can outweigh the hoped-for benefits (Bryan Johnson). It is NOT a self-medication candidate.

What the evidence says about timing

One verdict, worked out from every counted mention. One dot is one source: a researcher or a study. Tap a dot to see its receipt.

positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.

Not enough evidence

Once-weekly rapamycin works better for longevity than daily dosing.

1 source: 1 partly. Fewer than 3 sources so far.

Researchers say

1 partly

Studies show

No study counted yet.

6 more not counted · see why
We could not confirm who is speaking. 3
We could not tell what position it takes on this claim. 2
A host's remark inside an interview. 1
Show the receipts from 1 source

  1. Eric Verdin, on The Drive, at 1:16:47 Video · partly · Opinion

    “Um the reason why people adopted this sort of once weekly dose is to f first not have any imunosuppression”

Where the sources disagree

Built from every credited researcher and cited study on each claim.

On timing and the overall claim, no counted source takes a different side yet.

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Full Rapamycin Report

Every claim with its verdict and receipts

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Answers drawn from the corpus, with receipts

Timing is half the equation

You know when to take Rapamycin. A free account opens the interaction warnings for your whole stack. Pro adds chat about your own situation, drawn from 3,700+ hours of recorded interviews with 380 researchers and doctors, plus 48,500+ research studies.

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Rapamycin verdict