Dosage Lookup
Glutathione
Moderate
consensus
Direct glutathione supplementation: 250-500mg liposomal glutathione daily. To boost endogenous production: 600-1,800mg NAC daily, 300-600mg alpha-lipoic acid, methylated B vitamins, 200mcg selenium, and milk thistle. Hyman also uses IV glutathione in clinical settings for acute detoxification.
Consensus Protocol
Dosage
- Direct glutathione supplementation: 250-500mg liposomal glutathione daily
- To boost endogenous production: 600-1,800mg NAC daily, 300-600mg alpha-lipoic acid, methylated B vitamins, 200mcg selenium, and milk thistle
- Hyman also uses IV glutathione in clinical settings for acute detoxification
Form
- Liposomal glutathione for oral supplementation (best absorption)
- NAC capsules as the primary precursor
- Hyman also references intravenous and nebulized glutathione for clinical use in heavy metal detox, post-COVID, and acute illness
Timing
- Take liposomal glutathione on an empty stomach for best absorption
- NAC and supporting supplements (alpha-lipoic acid, B vitamins, selenium) can be taken with food
- Johnson takes his NAC in the morning as part of his Blueprint stack
Notes
- Direct glutathione supplementation has historically had poor oral bioavailability — liposomal forms address this
- Most experts focus on boosting endogenous production via NAC and dietary strategies rather than supplementing glutathione directly
- Sulfur-rich foods (garlic, onions, cruciferous vegetables) and bioactive whey protein are the primary dietary strategies to support glutathione production
Expert Positions
What Each Expert Says
On the Huberman Lab channel, glutathione is mentioned indirectly in a single episode featuring Dr. Rhonda Patrick. The discussion focuses on sulforaphane from broccoli sprouts activating the NRF2 pathway, which is crucial for detoxification and glutathione production. This is framed within a broader conversation about plant compounds, micronutrients, and stress response pathways — not as a direct recommendation for glutathione supplementation.
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More on Glutathione
Common Questions
How much Glutathione should you take?
Direct glutathione supplementation: 250-500mg liposomal glutathione daily. To boost endogenous production: 600-1,800mg NAC daily, 300-600mg alpha-lipoic acid, methylated B vitamins, 200mcg selenium, and milk thistle. Hyman also uses IV glutathione in clinical settings for acute detoxification.
What form of Glutathione is best?
Liposomal glutathione for oral supplementation (best absorption). NAC capsules as the primary precursor. Hyman also references intravenous and nebulized glutathione for clinical use in heavy metal detox, post-COVID, and acute illness.
When should you take Glutathione?
Take liposomal glutathione on an empty stomach for best absorption. NAC and supporting supplements (alpha-lipoic acid, B vitamins, selenium) can be taken with food. Johnson takes his NAC in the morning as part of his Blueprint stack.