Timing Protocol
What researchers say about when, how and with what to take glutathione, and how strong the evidence is.
The verdict on Glutathione overall
Leaning for
Glutathione supplements are worth taking.
15 sources: 2 positive, 11 partly, 2 negative
Short answer
Take liposomal glutathione on an empty stomach. NAC and the supporting supplements (alpha-lipoic acid, B vitamins, selenium) can go with food. NAC is taken in the morning in one daily stack (Bryan Johnson).
One verdict, worked out from every counted mention. One dot is one source: a researcher or a study. Tap a dot to see its receipt.
positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.
Liposomal glutathione is absorbed best on an empty stomach.
No counted mention yet.
Built from every credited researcher and cited study on each claim.
Glutathione supplements are worth taking.
Anne Shippy, on The Dr. Hyman Show, at 23:13
Positive Video · Opinion
Open the tape at 23:13 →“most people really benefit from uh doing some liposal glutathione and some liver support and some binders for at least 3 months”
Mark Hyman, 2 mentions on this claim
Positive Video
on The Dr. Hyman Show, at 16:26 · positive
“glutathione boosting stuff and acetylcysteine lipoic acid milk thistle a lot of other herbs can be used to help the Boost the body's detox Pathways”
on The Dr. Hyman Show, at 29:34 · partly
“you can help make more of it when you take certain supplements including an acetyl cysteine lipoic acid milk thistle”
Trial or observed group, J Cyst Fibros, 2008, PMID 18499536
Partly Study
Read the paper on PubMed →Use of a daily GSH regimen appears to be associated in CF patients with significant improvement in lung function and weight, and a significant decline in bacteria cultured in this uncontrolled study.
Controlled trial, Med Sci Monit, 2011, PMID 22129897
Partly Study
Read the paper on PubMed →Overall, the results suggest that oral and transdermal glutathioine supplementation may have some benefit on transsulfuration metabolites, but it is unclear whether the metabolites increased due to breakdown of glutathione.
Other primary study, J Int Soc Sports Nutr, 2015, PMID 25685110
Partly Study
Read the paper on PubMed →In contrast, the fatigue–inertia factor was significantly lower in the glutathione trial compared with the placebo trial (Z = −1.82, p < 0.05), while marked difference was not found in the VAS scores between trials (Z = −0.98, p = 0.163).
Controlled trial, Redox Biol, 2015, PMID 26262996
Partly Study
Read the paper on PubMed →The results of studies conducted with oral GSH are mixed [20,21] .
Other primary study, Clin Cosmet Investig Dermatol, 2017, PMID 28490897
Partly Study
Read the paper on PubMed →At some sites evaluated, subjects who received GSH showed a significant reduction in wrinkles compared with those taking placebo.
Trial or observed group, BMC Gastroenterol, 2017, PMID 28789631
Partly Study
Read the paper on PubMed →First, our study was a single-arm study without a control group.
Other primary study, Eur J Clin Nutr, 2018, PMID 28853742
Partly Study
Read the paper on PubMed →While, based on our previous study we would not expect significant changes to occur in the measured study outcomes , future placebo-controlled randomized trials with liposomal GSH will be required to confirm the specificity of its intervention effects.
Other primary study, Euroasian J Hepatogastroenterol, 2016, PMID 29201718
Partly Study
Read the paper on PubMed →Serum levels of ALT and 8-OHdG, but not GGT, were significantly decreased in NASH after treatment (p < 0.05) ( Figs 2A to C ).
Other primary study, Antioxidants (Basel), 2022, PMID 35624890
Partly Study
Read the paper on PubMed →Oral GSH Supplementation Increases Erythrocyte GSH and Decreases Oxidative Damage to DNA but Does Not Alter Glycemia in Diabetic Patients over a Period of Six Months
Other primary study, J Med Life, 2023, PMID 38585534
Partly Study
Read the paper on PubMed →However, it is worth noting that the observed difference between the groups was not statistically significant (P value >0.05).
Systematic review, Molecules, 2026, PMID 41900080
Partly Study
Read the paper on PubMed →To elucidate the clinical significance of glutathione, future research should focus on conducting randomized controlled trials, developing standardized formulations, and performing long-term safety assessments.
Other primary study, Eur J Clin Pharmacol, 1992, PMID 1362956
Negative Study
Read the paper on PubMed →Because of hydrolysis of glutathione by intestinal and hepatic gamma-glutamyltransferase, dietary glutathione is not a major determinant of circulating glutathione, and it is not possible to increase circulating glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 g of glutathione.
Controlled trial, J Pediatr Gastroenterol Nutr, 2020, PMID 32960827
Negative Study
Read the paper on PubMed →Oral glutathione supplementation did not impact growth or change serum or fecal inflammatory markers in pancreatic insufficient children with CF when compared to placebo.
Precis is not affiliated with or endorsed by YouTube or by any researcher, show or publisher we quote. We take no sponsorship, ad or affiliate money, and every verdict is our own review of what was said. How we stay independent
You know when to take Glutathione. A free account opens the interaction warnings for your whole stack. Pro adds chat about your own situation, drawn from 3,700+ hours of recorded interviews with 380 researchers and doctors, plus 48,500+ research studies.
Cancel anytime