Dosage Lookup

Fasting

4.1

Strong

consensus

Consensus Protocol

Dosage

  • 8-12 hour eating window for daily time-restricted feeding (Huberman: 8 hours
  • Patrick/Panda: 9-12 hours)
  • Johnson practices a more extreme 4-hour eating window (20-hour fast)

Form

Time-restricted eating (daily), periodic prolonged fasting (2-5 days, quarterly — Attia/Longo), or fasting-mimicking diet (5-day protocol, monthly to quarterly — Longo/Patrick).

Timing

  • Avoid food for at least 1 hour after waking and 2-3 hours before bed (Huberman)
  • Place the feeding window consistently within the 24-hour cycle to align with circadian rhythms
  • Early-day protein intake may benefit muscle maintenance and hormone optimization

Notes

  • Consistency of the feeding window matters more than the exact hours chosen
  • Light exercise (20-30 min walk) after the last meal can help transition into the fasted state
  • Salt water can help manage hunger and lightheadedness during fasting
  • Berberine can mimic some fasting effects on glucose disposal but should be used cautiously
  • Active women may need to approach fasting differently due to hormonal impacts

Expert Positions

Andrew Huberman
Andrew Huberman
Strongly Recommends TRF
Peter Attia
Peter Attia
Nuanced — Moved Away from Prolonged Fasts
Rhonda Patrick
Rhonda Patrick
Strongly Recommends for Autophagy & Circadian Health
Bryan Johnson
Bryan Johnson
Practices Strict Daily Fasting
Mark Hyman
Mark Hyman
Recommends as Hormetic Stress

What Each Expert Says

Andrew Huberman
Andrew Huberman
Strongly Recommends TRF

Huberman has two dedicated fasting episodes plus a guest interview with Dr. Satchin Panda. He provides the most actionable protocol: an 8-hour feeding window, no food for 1 hour after waking or 2-3 hours before bed, with consistent timing. He explains how eating raises blood glucose and insulin while fasting activates different hormonal pathways, and references Panda's 2012 mouse study showing time-restricted feeding prevents metabolic disease even on a high-fat diet. He also discusses how intermittent fasting improves liver enzymes and insulin sensitivity, and cautions about the sex-specific risks for active women via Dr. Stacy Sims.

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