Best Anti-Aging Supplements

All 5 experts actively recommend omega-3 supplementation, making this one of the strongest consensus topics. Patrick and Attia provide the deepest mechanistic coverage, Huberman recommends 1-3g EPA for mood and cognition, Hyman lists omega-3 as a foundational supplement everyone needs, and Johnson includes omega-3 sources in his Blueprint diet.

All 5 experts recognize glycine's value, though with varying emphasis. Attia personally supplements with glycine nightly for sleep. Johnson includes glycine in his Blueprint longevity stack as a daily staple. Huberman lists glycine as an optional sleep supplement alongside GABA and myo-inositol. Patrick highlights glycine through collagen peptides for connective tissue repair and wound healing. Hyman recommends glycine for sleep quality and nervous system relaxation.

All 5 experts mention astaxanthin positively, but with varying depth and enthusiasm. Hyman provides the most extensive coverage through a dedicated interview on astaxanthin's longevity mechanisms. Patrick highlights its role as a potent antioxidant in krill oil and salmon roe that activates the FOXO3 longevity gene. Attia discusses ITP data showing a 10% lifespan increase in male mice but notes more dose-response research is needed. Huberman recommends it specifically for eye health and ocular blood flow. Johnson includes astaxanthin in his Blueprint supplement stack without detailed commentary.

CoQ10 receives strong endorsement from Hyman, who has a dedicated deep dive and recommends it across 20+ videos as a cornerstone of mitochondrial support. Huberman mentions CoQ10 as a beneficial fertility supplement. Johnson includes CoQ10 in his Blueprint oral health protocol. Attia and Patrick do not specifically discuss CoQ10 supplementation in their analyzed content, though both emphasize mitochondrial health through other interventions.

4 of 5 experts support collagen for skin and connective tissue health, but Attia is notably skeptical — citing research showing collagen does not outperform whey protein for connective tissue synthesis. Johnson is the strongest advocate, taking collagen peptides daily in his Blueprint protocol. Huberman recommends it specifically for skin, not muscle. All experts agree collagen is inferior to whey for muscle building.

2 of 5 experts actively discuss glutathione supplementation or boosting strategies. Hyman is the dominant voice by far, dedicating significant portions of 29 videos to glutathione as 'the body's most important molecule' for detoxification, immune function, and chronic disease prevention. Johnson references glutathione in the context of biomarker tracking and air pollution defense. Huberman and Patrick mention glutathione only indirectly — through the NRF2 pathway and brain metabolism respectively — without recommending direct supplementation. Attia has no glutathione coverage in analyzed videos.

Rapamycin is the most polarizing longevity intervention among the 5 experts. Attia is the most bullish, cautiously prescribing it to patients and calling it a potential 'gold standard' geroprotective molecule. Johnson experimented with it extensively but discontinued after experiencing side effects and finding a pre-print suggesting it accelerated biological aging. Huberman explicitly avoids it, citing insufficient human data. Hyman mentions it favorably as a cutting-edge longevity therapy but provides no direct protocol. Patrick discusses the mTOR pathway extensively but does not cover rapamycin as a supplement.

Metformin is the most debated longevity drug among the 5 experts. Attia has extensively covered it across 27+ videos but shifted from cautious optimism to skepticism, concluding it may be a mitochondrial toxin for healthy individuals. Huberman explicitly avoids it for longevity. Hyman acknowledges it as the safest diabetes drug but favors lifestyle interventions over pharmacological approaches. Patrick has minimal coverage. Johnson includes metformin in his Blueprint protocol but is discussed only via Hyman's channel.

This is one of the most divisive topics among our 5 experts. Attia categorizes NAD supplementation as 'noise' on his evidence hierarchy, while Hyman actively advocates for NAD precursors as part of a longevity stack. Huberman personally takes NR and NMN for subjective energy but explicitly not for longevity. Patrick provides the most balanced scientific coverage, noting promising animal data but significant gaps in human evidence.