Expert Consensus Score
NMN & NAD+
Split Consensus
out of 5
Based on 29 videos across 5 experts · Updated 2026-03-19
Expert Positions
The Verdict
This is one of the most divisive topics among our 5 experts. Attia categorizes NAD supplementation as 'noise' on his evidence hierarchy, while Hyman actively advocates for NAD precursors as part of a longevity stack. Huberman personally takes NR and NMN for subjective energy but explicitly not for longevity. Patrick provides the most balanced scientific coverage, noting promising animal data but significant gaps in human evidence.
Quick Protocol
Dosage
NMN: 250-1000mg daily (Sinclair via Huberman: 1g; Hyman guests: 1000mg; Huberman personal: 1-2g). NR: 300-500mg daily (Huberman personal: 500mg). No consensus dosage exists.
Form
NMN sublingual or capsule. NR (as Niagen) is the most studied form. NAD+ IV infusions used occasionally for acute recovery (Huberman). Stability and bioavailability vary significantly between products.
Timing
Morning dosing is most common. Sinclair emphasizes pulsatile dosing — cycling on and off rather than continuous daily use. Take with food containing fat for resveratrol co-supplementation.
Key Findings
- NAD+ is a critical co-enzyme for energy metabolism, DNA repair (via PARP1), and sirtuin activation — its levels decline with age across multiple tissues.
- The ITP (Interventions Testing Program) failed to show lifespan extension with nicotinamide riboside (NR) in genetically diverse mice — a major blow to the longevity hypothesis (Attia).
- Attia categorizes NAD supplementation as 'noise' on his evidence hierarchy, below rapamycin ('promising') and metformin ('fuzzy').
- Huberman personally takes NR (500mg) and NMN (1-2g) daily for subjective energy benefits, not for longevity claims.
+ 4 more findings in the full report
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