Timing Protocol
What researchers say about when, how and with what to take phosphatidylserine, and how strong the evidence is.
The verdict on Phosphatidylserine overall
Leaning for
Phosphatidylserine is worth taking.
7 sources: 1 positive, 5 partly, 1 negative
Short answer
With meals; evening for cortisol management
One verdict, worked out from every counted mention. One dot is one source: a researcher or a study. Tap a dot to see its receipt.
positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.
Phosphatidylserine taken in the evening lowers cortisol.
2 sources: 1 positive, 1 partly. Fewer than 3 sources so far.
Researchers say
1 positive, 1 partly
Peter Attia, on The Drive, at 08:47
Positive Video · Opinion
Open the tape at 08:47 →“phosphatidylserine which suppresses the cortisol production in the evening and that actually helps facilitate sleep”
Dr. Sara Gottfried, on Huberman Lab, at 1:42:29
Partly Video · Opinion
Open the tape at 1:42:29 →“high at night who have what's known as a a flat cortisol pattern or a inverted pattern you want to take it at night”
Studies show
No study counted yet.
Peter Attia, on The Drive, at 08:47 Video · positive · Opinion
“phosphatidylserine which suppresses the cortisol production in the evening and that actually helps facilitate sleep”
Dr. Sara Gottfried, on Huberman Lab, at 1:42:29 Video · partly · Opinion
“high at night who have what's known as a a flat cortisol pattern or a inverted pattern you want to take it at night”
Built from every credited researcher and cited study on each claim.
Phosphatidylserine taken in the evening lowers cortisol.
Peter Attia, on The Drive, at 08:47
Positive Video · Opinion
Open the tape at 08:47 →“phosphatidylserine which suppresses the cortisol production in the evening and that actually helps facilitate sleep”
Dr. Sara Gottfried, on Huberman Lab, at 1:42:29
Partly Video · Opinion
Open the tape at 1:42:29 →“high at night who have what's known as a a flat cortisol pattern or a inverted pattern you want to take it at night”
Phosphatidylserine is worth taking.
Andrew Huberman, on Huberman Lab, at 29:07
Positive Video · Opinion
Open the tape at 29:07 →“But omega-3s, the EPAs, phosphatidylserine, and choline, it's obvious are going to improve brain function.”
Researchers
Peter Attia, on The Drive, at 08:44
Partly Video · Opinion
Open the tape at 08:44 →“so in those people I like to use something like phosphatidylserine which suppresses the cortisol production in the evening”
Studies
Other primary study, J Clin Biochem Nutr, 2010, PMID 21103034
Partly Study
Read the paper on PubMed →The scores significantly increased against the baseline in all 3 groups, with no difference between Soy-PS and placebo groups at any evaluation point.
Pooled analysis, J Altern Complement Med, 2021, PMID 33539192
Partly Study
Read the paper on PubMed →Preliminary evidence suggests that phosphatidylserine may be effective for reducing symptoms of inattention in children with ADHD, although the quality of the evidence is low and additional research in this area is warranted.
Controlled trial, Nutr J, 2025, PMID 41318468
Partly Study
Read the paper on PubMed →There were no differences in the primary or secondary outcomes in the total cohort.
Systematic review, Hum Psychopharmacol, 2026, PMID 42538853
Partly Study
Read the paper on PubMed →Given methodological limitations and high risk of bias, current evidence does not support citicoline or PS‐containing compounds as effective cognitive enhancers in mental disorders.
Trial or observed group, Nutr Neurosci, 2001, PMID 11842880
Negative Study
Read the paper on PubMed →In conclusion, a daily supplement of S-PS does not affect memory or other cognitive functions in older individuals with memory complaints.
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