Timing Protocol
What researchers say about when, how and with what to take boron, and how strong the evidence is.
The verdict on Boron overall
Leaning for
Boron is worth taking.
9 sources: 4 positive, 4 partly, 1 negative
Short answer
With meals
No timing claim on Boron has been checked yet. The timing notes above are not yet backed by counted mentions.
Built from every credited researcher and cited study on each claim.
Boron is worth taking.
Researchers
James DiNicolantonio, on The Dr. Hyman Show, at 50:45
Positive Video · Opinion
Open the tape at 50:45 →“lacking boron and manganese because those nutrients are very very difficult to source in the so diet those would be great to take”
Studies
Trial or observed group, J Trace Elem Med Biol, 2011, PMID 21129941
Positive Study
Read the paper on PubMed →After one week (in samples taken at 8.00 A.M, only), the mean plasma free testosterone increased and the mean plasma estradiol decreased significantly.
Controlled trial, Clin Interv Aging, 2014, PMID 24940052
Positive Study
Read the paper on PubMed →This comparative double-blind study has confirmed the effect of CFB, showing significant improvements in knee discomfort and function over a period of 2 weeks.
Controlled trial, Biol Trace Elem Res, 2015, PMID 25433580
Positive Study
Read the paper on PubMed →Consequently, CFB exerts beneficial effects on these subclinical blood markers within a healthy population.
Researchers
Dr. Kyle Gillett, 3 mentions on this claim
Partly Video
on Huberman Lab, at 18:22 · partly
“boron can acutely help lower it, usually in a dose of 5 to 12 mg per day. It's not really a sustained effect,”
on Huberman Lab, at 1:12:47 · partly
“So if you have a very high SHBG, boron can acutely help lower it”
on Huberman Lab, at 1:57:36 · partly
“so a lot of people take boron because it's probably not going to hurt and it will lower SHBG”
Studies
Controlled trial, Biol Trace Elem Res, 2011, PMID 21607703
Partly Study
Read the paper on PubMed →This study presents preliminary results that require further experimentation.
Controlled trial, J Trace Elem Med Biol, 2022, PMID 35183882
Partly Study
Read the paper on PubMed →However, we did not observe significant differences among groups post-intervention, in terms of hemoglobin concentrations and platelet count, in our study.
Trial or observed group, Biol Trace Elem Res, 1997, PMID 9197924
Partly Study
Read the paper on PubMed →However, there was no difference in plasma lipids or the oxidizability of low-density lipoprotein.
Other primary study, Br J Nutr, 1993, PMID 8329361
Negative Study
Read the paper on PubMed →Changing B intake from 0.33 to 3.33 mg/d had no effect on minerals, steroids or crosslinks.
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Tongkat Ali
Morning; cycle on/off monthly
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