Dosage Lookup
NMN & NAD+
Split
consensus
Consensus Protocol
Dosage
- NMN: 250-1000mg daily (Sinclair via Huberman: 1g
- Hyman guests: 1000mg
- Huberman personal: 1-2g)
- NR: 300-500mg daily (Huberman personal: 500mg)
- No consensus dosage exists
Form
- NMN sublingual or capsule
- NR (as Niagen) is the most studied form
- NAD+ IV infusions used occasionally for acute recovery (Huberman)
- Stability and bioavailability vary significantly between products
Timing
- Morning dosing is most common
- Sinclair emphasizes pulsatile dosing — cycling on and off rather than continuous daily use
- Take with food containing fat for resveratrol co-supplementation
Notes
- NMN is currently restricted as a commercial supplement due to FDA rulings classifying it as an investigational new drug
- NR remains available
- Exercise and fasting are proven to naturally boost NAD levels and should be prioritized over supplementation
- There is no consensus among our 5 experts that supplementation is necessary or beneficial for healthy individuals
Expert Positions
What Each Expert Says
Huberman has covered NMN/NAD+ extensively through two dedicated David Sinclair episodes and a personal AMA on longevity supplements. He personally takes NR (500mg) and NMN (1-2g) daily for subjective energy and uses NAD infusions occasionally for post-illness recovery. However, he explicitly states these are taken for perceived energy benefits rather than proven longevity effects. His Sinclair episodes cover the sirtuin pathway, epigenetic aging theory, and NMN as a NAD precursor in detail. A guest episode with Dr. Craig Koniver also discusses NAD+ for cellular energy production and mitochondrial health.
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