Dosage Lookup

NMN & NAD+

2.3

Split

consensus

NMN: 250-1000mg daily (Sinclair via Huberman: 1g; Hyman guests: 1000mg; Huberman personal: 1-2g). NR: 300-500mg daily (Huberman personal: 500mg). No consensus dosage exists.

Based on expert consensus data from publicly available videos, not medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement.

Consensus Protocol

Dosage

  • NMN: 250-1000mg daily (Sinclair via Huberman: 1g
  • Hyman guests: 1000mg
  • Huberman personal: 1-2g)
  • NR: 300-500mg daily (Huberman personal: 500mg)
  • No consensus dosage exists

Form

  • NMN sublingual or capsule
  • NR (as Niagen) is the most studied form
  • NAD+ IV infusions used occasionally for acute recovery (Huberman)
  • Stability and bioavailability vary significantly between products

Timing

  • Morning dosing is most common
  • Sinclair emphasizes pulsatile dosing — cycling on and off rather than continuous daily use
  • Take with food containing fat for resveratrol co-supplementation

Notes

  • NMN is currently restricted as a commercial supplement due to FDA rulings classifying it as an investigational new drug
  • NR remains available
  • Exercise and fasting are proven to naturally boost NAD levels and should be prioritized over supplementation
  • There is no consensus among our 5 experts that supplementation is necessary or beneficial for healthy individuals

Expert Positions

Andrew Huberman
Andrew Huberman
Takes It, But Not for Longevity
Peter Attia
Peter Attia
Categorizes as 'Noise'
Rhonda Patrick
Rhonda Patrick
Promising but Unproven in Humans
Bryan Johnson
Bryan Johnson
No Direct Coverage
Mark Hyman
Mark Hyman
Advocates for NAD Precursors

What Each Expert Says

Andrew Huberman
Andrew Huberman
Takes It, But Not for Longevity

Huberman has covered NMN/NAD+ extensively through two dedicated David Sinclair episodes and a personal AMA on longevity supplements. He personally takes NR (500mg) and NMN (1-2g) daily for subjective energy and uses NAD infusions occasionally for post-illness recovery. However, he explicitly states these are taken for perceived energy benefits rather than proven longevity effects. His Sinclair episodes cover the sirtuin pathway, epigenetic aging theory, and NMN as a NAD precursor in detail. A guest episode with Dr. Craig Koniver also discusses NAD+ for cellular energy production and mitochondrial health.

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More on NMN & NAD+

Consensus Score Which Form? When to Take Check Your Stack

Common Questions

How much NMN & NAD+ should you take?

NMN: 250-1000mg daily (Sinclair via Huberman: 1g; Hyman guests: 1000mg; Huberman personal: 1-2g). NR: 300-500mg daily (Huberman personal: 500mg). No consensus dosage exists.

What form of NMN & NAD+ is best?

NMN sublingual or capsule. NR (as Niagen) is the most studied form. NAD+ IV infusions used occasionally for acute recovery (Huberman). Stability and bioavailability vary significantly between products.

When should you take NMN & NAD+?

Morning dosing is most common. Sinclair emphasizes pulsatile dosing — cycling on and off rather than continuous daily use. Take with food containing fat for resveratrol co-supplementation.

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