Which Form?
NMN & NAD+
Split
consensus
Available Forms
- NMN sublingual or capsule
- NR (as Niagen) is the most studied form
- NAD+ IV infusions used occasionally for acute recovery (Huberman)
- Stability and bioavailability vary significantly between products
Dosage & Timing
Dosage
- NMN: 250-1000mg daily (Sinclair via Huberman: 1g
- Hyman guests: 1000mg
- Huberman personal: 1-2g)
- NR: 300-500mg daily (Huberman personal: 500mg)
- No consensus dosage exists
Timing
- Morning dosing is most common
- Sinclair emphasizes pulsatile dosing — cycling on and off rather than continuous daily use
- Take with food containing fat for resveratrol co-supplementation
Expert Positions
What Each Expert Says
Huberman has covered NMN/NAD+ extensively through two dedicated David Sinclair episodes and a personal AMA on longevity supplements. He personally takes NR (500mg) and NMN (1-2g) daily for subjective energy and uses NAD infusions occasionally for post-illness recovery. However, he explicitly states these are taken for perceived energy benefits rather than proven longevity effects. His Sinclair episodes cover the sirtuin pathway, epigenetic aging theory, and NMN as a NAD precursor in detail. A guest episode with Dr. Craig Koniver also discusses NAD+ for cellular energy production and mitochondrial health.
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