Does NMN improve insulin sensitivity? 3 of 3 studies agree

Does NMN improve insulin sensitivity?

The claim checked: A 10-week trial of 250 mg NMN improved insulin sensitivity Hear it at 28:06

What do the studies say?

Leaning for

All three studies point to one trial: muscle insulin sensitivity rose 25% after 10 weeks of NMN, in overweight postmenopausal women with prediabetes.

Computed from 3 studies that test this point, each judged by two readers, in full. 1 more study is waiting for a full read and does not count yet.

What was said on the podcast?

“this was a 10-week study. It's it's well done. It's randomized, placebo-controlled. It was 250 mg, which is a relatively low dose. Remember, I'm taking in my clinical trials are at a gram and 2 grams. This is 250 mg. Nevertheless, it improved what you said, insulin-stimulated glucose disposal. That's basically insulin sensitivity.”

David Sinclair, Lifespan · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4 · 28:06 on YouTube
Comes up in 8 episodes of the show.

The point checked Leaning for

A 10-week randomized placebo-controlled trial of 250 mg NMN (Yoshino 2021) improved insulin-stimulated glucose disposal

Agree 3

pooled analysis · 2024

“Only one included NMN trial recruited prediabetic participants which showed improved insulin sensitivity in muscle.”

Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials. Curr Diab Rep
Who: adults 18+ in double-blind RCTs of oral NMN vs placebo, mostly healthy middle-aged; one trial (Yoshino 2021) of 25 prediabetic postmenopausal women with overweight/obesity
PMID 39531138

controlled trial · 2021 · cited on tape

“Muscle insulin sensitivity, assessed as the rate of insulin-stimulated glucose disposal per kg of fat-free mass during the clamp procedure, was 25±7% greater after than before 10 weeks of NMN supplementation (p<0.01), but was not different after than before placebo treatment (Fig. 2A).”

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science
Who: Postmenopausal women with prediabetes who were overweight or obese (BMI 25.3-39.1)
PMID 33888596

pooled analysis · 2026

“In particular, Yoshino 2021 [ 26 ] used the glucose clamp technique in overweight or obese postmenopausal women with prediabetes and observed improvements in peripheral insulin sensitivity-related indicators in the NMN group.”

Safety and Metabolism-Related Outcomes of Oral Nicotinamide Mononucleotide Supplementation in Adults: A Systematic Review and Meta-Analysis. Nutrients
Who: Adults in RCTs of oral NMN (healthy, older, overweight/obese, prediabetic, T2DM, hypertensive); the Yoshino 2021 trial was overweight or obese postmenopausal women with prediabetes
PMID 42514320

Partly agree 0

None.

Disagree 0