Weight loss / metabolic (GLP-1)
Semaglutide
Ozempic, Wegovy
FDA-approved, strong human data
Based on expert consensus from publicly available videos plus public FDA/regulatory status — not medical advice. Peptides are prescription territory; consult a physician before using anything here.
The Verdict
The most-established GLP-1 — real trials, real weight loss, and cardiovascular benefit. The catch experts stress is muscle loss: pair it with protein and resistance training.
The Evidence
FDA / Legal Status
FDA-approved (type 2 diabetes and obesity)
Human Evidence
Large randomized trials (STEP, SELECT) — ~15% average weight loss plus cardiovascular benefit
Sport / Doping
Not a typical doping agent; prescription drug
Safety Flags
- Significant lean-muscle loss without protein + resistance training (Attia calls the rate 'alarming')
- GI side effects (nausea, vomiting) during titration; weight regain common if stopped
Who Covers It
Other experts in the panel had no substantive coverage of this peptide — we don't guess their position.
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