Weight loss / metabolic (investigational)
Triple agonist (GLP-1 + GIP + glucagon)
Verdict
Leaning for
GLP-1 drugs are worth taking for people with obesity.
18 sources: 6 positive, 9 partly, 3 negative
In short
The most potent GLP-1 on the horizon (~25-30% weight loss in its 2026 Phase 3 trial), but still investigational. No source in our corpus covers it directly, and gray-market vials are a real risk.
positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.
GLP-1 drugs are worth taking for people with obesity.
18 sources: 6 positive, 9 partly, 3 negative.
Researchers say
6 positive, 9 partly, 2 negative
James O'Keefe, on The Drive, at 1:35:24
Positive Video · Opinion
Open the tape at 1:35:24 →“these are wonderful drugs for weight loss i'm using some of my patients now high dose semi blue type”
Stephan Guyenet, on The Drive, at 2:08:52
Positive Video · Opinion
Open the tape at 2:08:52 →“i think it's worthwhile to consider medical treatment so something like semaglotide for example”
Dr. Zachary Knight, 2 mentions on this claim
Positive Video
on Huberman Lab, at 1:40:33 · positive
“the gp1 drugs have just a lot of benefits even Beyond weight loss so people might not want to stop taking them”
on Huberman Lab, at 2:14:33 · positive
“you couldn't have asked for more so far at this stage with these with these glp1 drugs um incredible uh weight loss”
Dr. Layne Norton, on Huberman Lab, at 2:24:10
Positive Video · Opinion
Open the tape at 2:24:10 →“I think they appear to be great tools for people reducing their intake and reducing body fat”
Abu Bakri, on Huberman Lab, at 2:22:13
Positive Video · Opinion
Open the tape at 2:22:13 →“these medications are good kind of transforming medicine especially where where I practice”
Dr. Thaïs Aliabadi, 2 mentions on this claim
Positive Video
on Huberman Lab, at 1:10:13 · positive
“in 2014 back then I had trulicity as GLP1 and that's what I used to use for my PCOS patients and they would lose 50 60 80 100 pounds and this is 2014.”
on Huberman Lab, at 1:15:21 · positive
“it's the first time in their life that something actually works for them”
Dr. Gabrielle Lyon, 2 mentions on this claim
Partly Video
on Huberman Lab, at 2:36:15 · positive
“we have used these in clinic and it has trans formed their lives I would never take that away from somebody”
on The Diary Of A CEO, at 1:01:52 · partly
“it depends on how long you've been struggling”
Tina Moore, 3 mentions on this claim
Partly Video
on The Diary Of A CEO, at 1:27:36 · positive
“it gives people this wonderful window of opportunity to be back in the driver's seat”
on The Diary Of A CEO, at 1:14:03 · partly
“if you're severely diabetic or obese I could see the rationale I'm arguing I still don't think that's necessary”
on The Diary Of A CEO, at 1:40:07 · partly
“I have seen them successfully micro doing so long as they take that opportunity to do all the things”
Dr. Mary Claire Haver, on Huberman Lab, at 1:58:15
Partly Video · Opinion
Open the tape at 1:58:15 →“think that they can be a really important tool for a lot of patients I don't think they're for everyone”
Abby Smith-Ryan, on The Drive, at 1:04:03
Partly Video · Opinion
Open the tape at 1:04:03 →“I would say 130 to 150 grams of protein”
Dr. Peter Attia, on Huberman Lab, at 2:42:02
Partly Video · Opinion
Open the tape at 2:42:02 →“I think the GLP-1 agonists have more efficacy, and, you know, for all intensity and for everything we can see, certainly seem safer.”
Stacy Sims, on The Diary Of A CEO, at 51:26
Partly Video · Opinion
Open the tape at 51:26 →“No, because most of the people that come to see me have those 10 vanity pounds they want to lose.”
Dr. Mark Hyman, on Huberman Lab, at 1:47:20
Partly Video · Opinion
Open the tape at 1:47:20 →“it should be illegal to prescribe these drugs unless they're combined with a nutrition consult”
Dr. Robert Lustig, on Huberman Lab, at 2:57:29
Partly Video · Opinion
Open the tape at 2:57:29 →“I'm for them for the right patient and right now it's not the right patient who's getting them”
Dr Will Bulsiewicz, on The Diary Of A CEO, at 59:52
Partly Video · Opinion
Open the tape at 59:52 →“for people who need it it's I'm glad it's there um I don't think that the entire world needs OIC”
Dr. Mindy Pelz, on The Diary Of A CEO, at 1:49:42
Negative Video · Opinion
Open the tape at 1:49:42 →“it's at the expense of muscle they're actually losing more muscle than they are losing fat”
Dr. Ralph DeFronzo, on The Drive, at 04:18
Negative Video · Opinion
Open the tape at 04:18 →“I put you on the drug you lose weight you stop the drug you regain the weight this a huge Public Health concern”
Studies show
1 negative
1 cited on tape, not yet checked against the paper
STEP 1, cited on The Dr. Hyman Show, at 24:19
Negative Study
Open the tape at 24:19 →“in this one study called the step one trial semaglutide treatment effect in people with obesity it was a randomized control trial where they found that uh two-thirds of people regain the weight they lost two years after discontinuing”
James O'Keefe, on The Drive, at 1:35:24 Video · positive · Opinion
“these are wonderful drugs for weight loss i'm using some of my patients now high dose semi blue type”
Stephan Guyenet, on The Drive, at 2:08:52 Video · positive · Opinion
“i think it's worthwhile to consider medical treatment so something like semaglotide for example”
Dr. Zachary Knight Video · positive · 2 mentions
on Huberman Lab, at 1:40:33 · positive · Opinion
“the gp1 drugs have just a lot of benefits even Beyond weight loss so people might not want to stop taking them”
on Huberman Lab, at 2:14:33 · positive · Opinion
“you couldn't have asked for more so far at this stage with these with these glp1 drugs um incredible uh weight loss”
Dr. Layne Norton, on Huberman Lab, at 2:24:10 Video · positive · Opinion
“I think they appear to be great tools for people reducing their intake and reducing body fat”
Abu Bakri, on Huberman Lab, at 2:22:13 Video · positive · Opinion
“these medications are good kind of transforming medicine especially where where I practice”
Dr. Thaïs Aliabadi Video · positive · 2 mentions
on Huberman Lab, at 1:10:13 · positive · Opinion
“in 2014 back then I had trulicity as GLP1 and that's what I used to use for my PCOS patients and they would lose 50 60 80 100 pounds and this is 2014.”
on Huberman Lab, at 1:15:21 · positive · Opinion
“it's the first time in their life that something actually works for them”
Dr. Gabrielle Lyon Video · partly · 2 mentions
on Huberman Lab, at 2:36:15 · positive · Opinion
“we have used these in clinic and it has trans formed their lives I would never take that away from somebody”
on The Diary Of A CEO, at 1:01:52 · partly · Opinion
“it depends on how long you've been struggling”
Tina Moore Video · partly · 3 mentions
on The Diary Of A CEO, at 1:27:36 · positive · Opinion
“it gives people this wonderful window of opportunity to be back in the driver's seat”
on The Diary Of A CEO, at 1:14:03 · partly · Opinion
“if you're severely diabetic or obese I could see the rationale I'm arguing I still don't think that's necessary”
on The Diary Of A CEO, at 1:40:07 · partly · Opinion
“I have seen them successfully micro doing so long as they take that opportunity to do all the things”
Dr. Mary Claire Haver, on Huberman Lab, at 1:58:15 Video · partly · Opinion
“think that they can be a really important tool for a lot of patients I don't think they're for everyone”
Abby Smith-Ryan, on The Drive, at 1:04:03 Video · partly · Opinion
“I would say 130 to 150 grams of protein”
Dr. Peter Attia, on Huberman Lab, at 2:42:02 Video · partly · Opinion
“I think the GLP-1 agonists have more efficacy, and, you know, for all intensity and for everything we can see, certainly seem safer.”
Stacy Sims, on The Diary Of A CEO, at 51:26 Video · partly · Opinion
“No, because most of the people that come to see me have those 10 vanity pounds they want to lose.”
Dr. Mark Hyman, on Huberman Lab, at 1:47:20 Video · partly · Opinion
“it should be illegal to prescribe these drugs unless they're combined with a nutrition consult”
Dr. Robert Lustig, on Huberman Lab, at 2:57:29 Video · partly · Opinion
“I'm for them for the right patient and right now it's not the right patient who's getting them”
Dr Will Bulsiewicz, on The Diary Of A CEO, at 59:52 Video · partly · Opinion
“for people who need it it's I'm glad it's there um I don't think that the entire world needs OIC”
Dr. Mindy Pelz, on The Diary Of A CEO, at 1:49:42 Video · negative · Opinion
“it's at the expense of muscle they're actually losing more muscle than they are losing fat”
Dr. Ralph DeFronzo, on The Drive, at 04:18 Video · negative · Opinion
“I put you on the drug you lose weight you stop the drug you regain the weight this a huge Public Health concern”
STEP 1, cited on The Dr. Hyman Show, at 24:19 Study · negative
“in this one study called the step one trial semaglutide treatment effect in people with obesity it was a randomized control trial where they found that uh two-thirds of people regain the weight they lost two years after discontinuing”
Where the sources disagree
GLP-1 drugs are worth taking for people with obesity.
James O'Keefe, on The Drive, at 1:35:24
Positive Video · Opinion
Open the tape at 1:35:24 →“these are wonderful drugs for weight loss i'm using some of my patients now high dose semi blue type”
Stephan Guyenet, on The Drive, at 2:08:52
Positive Video · Opinion
Open the tape at 2:08:52 →“i think it's worthwhile to consider medical treatment so something like semaglotide for example”
Dr. Zachary Knight, 2 mentions on this claim
Positive Video
on Huberman Lab, at 1:40:33 · positive
“the gp1 drugs have just a lot of benefits even Beyond weight loss so people might not want to stop taking them”
on Huberman Lab, at 2:14:33 · positive
“you couldn't have asked for more so far at this stage with these with these glp1 drugs um incredible uh weight loss”
Dr. Layne Norton, on Huberman Lab, at 2:24:10
Positive Video · Opinion
Open the tape at 2:24:10 →“I think they appear to be great tools for people reducing their intake and reducing body fat”
Abu Bakri, on Huberman Lab, at 2:22:13
Positive Video · Opinion
Open the tape at 2:22:13 →“these medications are good kind of transforming medicine especially where where I practice”
Dr. Thaïs Aliabadi, 2 mentions on this claim
Positive Video
on Huberman Lab, at 1:10:13 · positive
“in 2014 back then I had trulicity as GLP1 and that's what I used to use for my PCOS patients and they would lose 50 60 80 100 pounds and this is 2014.”
on Huberman Lab, at 1:15:21 · positive
“it's the first time in their life that something actually works for them”
Dr. Gabrielle Lyon, 2 mentions on this claim
Partly Video
on Huberman Lab, at 2:36:15 · positive
“we have used these in clinic and it has trans formed their lives I would never take that away from somebody”
on The Diary Of A CEO, at 1:01:52 · partly
“it depends on how long you've been struggling”
Tina Moore, 3 mentions on this claim
Partly Video
on The Diary Of A CEO, at 1:27:36 · positive
“it gives people this wonderful window of opportunity to be back in the driver's seat”
on The Diary Of A CEO, at 1:14:03 · partly
“if you're severely diabetic or obese I could see the rationale I'm arguing I still don't think that's necessary”
on The Diary Of A CEO, at 1:40:07 · partly
“I have seen them successfully micro doing so long as they take that opportunity to do all the things”
Dr. Mary Claire Haver, on Huberman Lab, at 1:58:15
Partly Video · Opinion
Open the tape at 1:58:15 →“think that they can be a really important tool for a lot of patients I don't think they're for everyone”
Abby Smith-Ryan, on The Drive, at 1:04:03
Partly Video · Opinion
Open the tape at 1:04:03 →“I would say 130 to 150 grams of protein”
Dr. Peter Attia, on Huberman Lab, at 2:42:02
Partly Video · Opinion
Open the tape at 2:42:02 →“I think the GLP-1 agonists have more efficacy, and, you know, for all intensity and for everything we can see, certainly seem safer.”
Stacy Sims, on The Diary Of A CEO, at 51:26
Partly Video · Opinion
Open the tape at 51:26 →“No, because most of the people that come to see me have those 10 vanity pounds they want to lose.”
Dr. Mark Hyman, on Huberman Lab, at 1:47:20
Partly Video · Opinion
Open the tape at 1:47:20 →“it should be illegal to prescribe these drugs unless they're combined with a nutrition consult”
Dr. Robert Lustig, on Huberman Lab, at 2:57:29
Partly Video · Opinion
Open the tape at 2:57:29 →“I'm for them for the right patient and right now it's not the right patient who's getting them”
Dr Will Bulsiewicz, on The Diary Of A CEO, at 59:52
Partly Video · Opinion
Open the tape at 59:52 →“for people who need it it's I'm glad it's there um I don't think that the entire world needs OIC”
Researchers
Dr. Mindy Pelz, on The Diary Of A CEO, at 1:49:42
Negative Video · Opinion
Open the tape at 1:49:42 →“it's at the expense of muscle they're actually losing more muscle than they are losing fat”
Dr. Ralph DeFronzo, on The Drive, at 04:18
Negative Video · Opinion
Open the tape at 04:18 →“I put you on the drug you lose weight you stop the drug you regain the weight this a huge Public Health concern”
Studies
STEP 1, cited on The Dr. Hyman Show, at 24:19
Negative Study
Open the tape at 24:19 →“in this one study called the step one trial semaglutide treatment effect in people with obesity it was a randomized control trial where they found that uh two-thirds of people regain the weight they lost two years after discontinuing”
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