Dosage Lookup
GLP-1 Agonists
Moderate
consensus
Consensus Protocol
Dosage
- Semaglutide: typically starts at 0
- 25mg/week, titrated up to 2
- 4mg/week for weight management
- Tirzepatide: starts at 2
- 5mg/week, titrated up to 15mg/week
- Dosing is individualized by a prescribing physician (Attia)
Form
- Injectable (subcutaneous, once weekly)
- Oral formulations are in development
- Some clinicians use compounded peptide formulations at lower doses (Attia, Koniver)
Timing
- Once-weekly injection
- No specific time-of-day requirement
- Must be combined with strength training and high protein intake (minimum 1g per pound of lean body mass) to mitigate muscle loss (Attia)
Notes
- This is a prescription medication — not a supplement
- Requires physician oversight, regular monitoring via DEXA scans for body composition, and blood work
- Compounded versions from reputable pharmacies may offer lower-dose options
- High cost remains a significant barrier to access (Attia)
- Hyman strongly advocates addressing diet and lifestyle first before considering pharmaceutical intervention
Expert Positions
What Each Expert Says
Huberman covers GLP-1 agonists across multiple contexts: hunger neuroscience, peptide therapy, and fat loss protocols. He features Dr. Zachary Knight (UCSF) explaining the mechanism of GLP-1 drugs, their origin from Gila monster venom, and the evolution from short-acting to long-acting forms. He discusses how GLP-1 acts on brain stem and hypothalamic circuits to suppress appetite. In peptide therapy episodes, Dr. Craig Koniver discusses micro-dosing semaglutide and tirzepatide to mitigate side effects. Huberman also frequently mentions yerba mate as a natural GLP-1 stimulator for fat loss.
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