Timing Protocol
What researchers say about when, how and with what to take glp-1 agonists, and how strong the evidence is.
The verdict on GLP-1 Agonists overall
Leaning for
GLP-1 drugs are worth taking for people with obesity.
18 sources: 6 positive, 9 partly, 3 negative
Short answer
Once-weekly injection, at any time of day. Pair it with strength training and high protein (at least 1g per pound of lean body mass) to limit muscle loss (Peter Attia).
No timing claim on GLP-1 Agonists has been checked yet. The timing notes above are not yet backed by counted mentions.
Built from every credited researcher and cited study on each claim.
GLP-1 drugs are worth taking for people with obesity.
James O'Keefe, on The Drive, at 1:35:24
Positive Video · Opinion
Open the tape at 1:35:24 →“these are wonderful drugs for weight loss i'm using some of my patients now high dose semi blue type”
Stephan Guyenet, on The Drive, at 2:08:52
Positive Video · Opinion
Open the tape at 2:08:52 →“i think it's worthwhile to consider medical treatment so something like semaglotide for example”
Dr. Zachary Knight, 2 mentions on this claim
Positive Video
on Huberman Lab, at 1:40:33 · positive
“the gp1 drugs have just a lot of benefits even Beyond weight loss so people might not want to stop taking them”
on Huberman Lab, at 2:14:33 · positive
“you couldn't have asked for more so far at this stage with these with these glp1 drugs um incredible uh weight loss”
Dr. Layne Norton, on Huberman Lab, at 2:24:10
Positive Video · Opinion
Open the tape at 2:24:10 →“I think they appear to be great tools for people reducing their intake and reducing body fat”
Abu Bakri, on Huberman Lab, at 2:22:13
Positive Video · Opinion
Open the tape at 2:22:13 →“these medications are good kind of transforming medicine especially where where I practice”
Dr. Thaïs Aliabadi, 2 mentions on this claim
Positive Video
on Huberman Lab, at 1:10:13 · positive
“in 2014 back then I had trulicity as GLP1 and that's what I used to use for my PCOS patients and they would lose 50 60 80 100 pounds and this is 2014.”
on Huberman Lab, at 1:15:21 · positive
“it's the first time in their life that something actually works for them”
Dr. Gabrielle Lyon, 2 mentions on this claim
Partly Video
on Huberman Lab, at 2:36:15 · positive
“we have used these in clinic and it has trans formed their lives I would never take that away from somebody”
on The Diary Of A CEO, at 1:01:52 · partly
“it depends on how long you've been struggling”
Tina Moore, 3 mentions on this claim
Partly Video
on The Diary Of A CEO, at 1:27:36 · positive
“it gives people this wonderful window of opportunity to be back in the driver's seat”
on The Diary Of A CEO, at 1:14:03 · partly
“if you're severely diabetic or obese I could see the rationale I'm arguing I still don't think that's necessary”
on The Diary Of A CEO, at 1:40:07 · partly
“I have seen them successfully micro doing so long as they take that opportunity to do all the things”
Dr. Mary Claire Haver, on Huberman Lab, at 1:58:15
Partly Video · Opinion
Open the tape at 1:58:15 →“think that they can be a really important tool for a lot of patients I don't think they're for everyone”
Abby Smith-Ryan, on The Drive, at 1:04:03
Partly Video · Opinion
Open the tape at 1:04:03 →“I would say 130 to 150 grams of protein”
Dr. Peter Attia, on Huberman Lab, at 2:42:02
Partly Video · Opinion
Open the tape at 2:42:02 →“I think the GLP-1 agonists have more efficacy, and, you know, for all intensity and for everything we can see, certainly seem safer.”
Stacy Sims, on The Diary Of A CEO, at 51:26
Partly Video · Opinion
Open the tape at 51:26 →“No, because most of the people that come to see me have those 10 vanity pounds they want to lose.”
Dr. Mark Hyman, on Huberman Lab, at 1:47:20
Partly Video · Opinion
Open the tape at 1:47:20 →“it should be illegal to prescribe these drugs unless they're combined with a nutrition consult”
Dr. Robert Lustig, on Huberman Lab, at 2:57:29
Partly Video · Opinion
Open the tape at 2:57:29 →“I'm for them for the right patient and right now it's not the right patient who's getting them”
Dr Will Bulsiewicz, on The Diary Of A CEO, at 59:52
Partly Video · Opinion
Open the tape at 59:52 →“for people who need it it's I'm glad it's there um I don't think that the entire world needs OIC”
Researchers
Dr. Mindy Pelz, on The Diary Of A CEO, at 1:49:42
Negative Video · Opinion
Open the tape at 1:49:42 →“it's at the expense of muscle they're actually losing more muscle than they are losing fat”
Dr. Ralph DeFronzo, on The Drive, at 04:18
Negative Video · Opinion
Open the tape at 04:18 →“I put you on the drug you lose weight you stop the drug you regain the weight this a huge Public Health concern”
Studies
STEP 1, cited on The Dr. Hyman Show, at 24:19
Negative Study
Open the tape at 24:19 →“in this one study called the step one trial semaglutide treatment effect in people with obesity it was a randomized control trial where they found that uh two-thirds of people regain the weight they lost two years after discontinuing”
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