Expert Position

What does Peter Attia say about rapamycin?

Q: Does Peter Attia take rapamycin?

He said so in January 2020. He called it probably the single most out-there thing he does, and said he was standing on a large body of animal evidence. That is the most recent statement of personal use in the videos we analyse. The newest rapamycin material of any kind here is from 2022. Treat it as what he said then, not as a current protocol.

Physician focused on longevity and healthspan, host of The Drive

In January 2020 Peter Attia said he takes rapamycin. He has never stated his own dose on air. The newest rapamycin material in this corpus is from 2022. The dosing he discusses is weekly, not daily. It comes from the trial that changed his mind, which tested 5mg and 20mg once-weekly arms.

On the record

The trial dosing he points to (2020) - a study's arms, not a recommendation

“there are different ways that you can dose it two of the three treatment arms in that study were only being given rapamycin once a week one at five milligrams one at twenty milligrams”

Peter Attia · Jul 2020 · watch @ 22:20 →

What Peter actually says

• He said he takes it - in January 2020. We date that deliberately: it is the most recent statement of personal use in this corpus, and a six-year-old sentence is not evidence of what anyone takes today.
• He has never published a personal dose here, at any point. Any specific "Attia rapamycin protocol" you find elsewhere is not something he said on these tapes.
• The dosing conversation on his show is weekly, not daily - the trial he points to as his turning point used once-weekly dosing at 5mg and 20mg.
• He talks openly about side effects, mouth sores in particular. He also notes that rapamycin and everolimus get used near-interchangeably in this literature.
• Rapamycin is a prescription drug used off-label here. This page reports what he said on video; it is not a protocol.

Where the other four land

None of the other 4 experts takes a positive position on Rapamycin.

Andrew Huberman Explicitly Avoids It

Rhonda Patrick Discusses mTOR, Not Rapamycin

Bryan Johnson Tried and Discontinued

Mark Hyman Mentions Favorably, No Protocol

Common Questions

Does Peter Attia take rapamycin?

He said so in January 2020. He called it probably the single most out-there thing he does, and said he was standing on a large body of animal evidence. That is the most recent statement of personal use in the videos we analyse. The newest rapamycin material of any kind here is from 2022. Treat it as what he said then, not as a current protocol.

What dose of rapamycin does Peter Attia take?

He does not say in this corpus. The dosing he discusses comes from the trial he credits as his turning point. That trial gave rapamycin once a week, in 5mg and 20mg arms. That is the study's design, not his personal protocol.

Is rapamycin taken daily for longevity?

The dosing discussed on his show is weekly rather than daily. Weekly dosing is the pattern used in the trial he points to, and the rationale is intermittent rather than continuous mTOR inhibition.

What are the side effects Attia discusses?

Mouth sores come up most often, and he has hosted extended discussion of the risks of off-label use. He also notes that rapamycin and everolimus are used near-interchangeably in this research.

See Peter Attia's full supplement stack.