What is a good ApoB level?

There isn't one universal "good" number, but the experts who cover ApoB agree on the direction: aim lower than the lab's "normal" flag. ApoB measures the NUMBER of atherogenic particles (LDL, VLDL, Lp(a)) rather than the cholesterol mass they carry — which is why Attia, Patrick, and Huberman treat it as a more complete picture of cardiovascular risk than LDL-C.

Attia is the most specific. He argues for early, aggressive lowering and points to two reference points: the much lower ApoB levels seen in children (he cites roughly 20-40 mg/dL) as a safety/efficacy benchmark, and a working ceiling around 60 mg/dL for people in their late 30s and early 40s. His reasoning is that ApoB is a causal driver of atherosclerosis (citing Mendelian randomization), and standard 10-year risk calculators lean on age and sex while ignoring the underlying disease — so he'd rather measure ApoB directly and act early. He's explicit that hitting low targets often takes diet plus medication (statins, ezetimibe, bempedoic acid, PCSK9 inhibitors) under a doctor's care.

Hyman reaches a similar place from the metabolic side: advanced lipid particle analysis (ApoB, Lp(a)) beats a standard panel, and a "normal" LDL can hide an unsafe particle count — many heart-attack victims have normal LDL. Two honest caveats: ApoB often isn't on a basic cholesterol panel, so you may have to request advanced lipid testing; and this is educational synthesis, not medical advice — what your target should be, and whether to add medication, is a decision for your physician.