other primary study · 2023 · landmark
“Participants in the healthy lifestyle group had significantly lower adjusted cumulative mortality rates than those in the unhealthy lifestyle group, with an adjusted HR of 0·60 (95% CI 0·54–0·67) in participants at a low genetic risk and 0·59 (0·54–0·66) in participants at a high genetic risk (figure 2).”
Healthy lifestyle in late-life, longevity genes, and life expectancy among older adults: a 20-year, population-based, prospective cohort study. Lancet Healthy Longev
Who: Chinese adults aged 65 years and older (median age 90) in the Chinese Longitudinal Healthy Longevity Survey, 23 provinces
PMID 37804845
other primary study · 2023 · landmark
“Ideal CVH was associated with lower cardiovascular outcomes and all-cause mortality, with a more pronounced association observed in individuals with high PRS for CVD.”
Relation of Life's Essential 8 to the genetic predisposition for cardiovascular outcomes and all-cause mortality: results from a national prospective cohort. Eur J Prev Cardiol
Who: UK Biobank participants aged 40-69 at recruitment (2006-2010) with genotype data and complete Life's Essential 8 metrics
PMID 37228091
other primary study · 2011
“Having never smoked, healthy diet, adequate physical activity, and moderate alcohol consumption were each significantly associated with a reduced risk of mortality, and the number of these behaviors was inversely associated with the risk for mortality.”
Low-risk lifestyle behaviors and all-cause mortality: findings from the National Health and Nutrition Examination Survey III Mortality Study. Am J Public Health
Who: Nationally representative US participants aged 17 and older in NHANES III (1988-1994), including Whites, African Americans and Mexican Americans
PMID 21852630
other primary study · 2021
“Conclusions Findings from this prospective population-based cohort study suggest an unhealthy lifestyle, based on smoking, having overweight or obesity, having lower diet quality, sub-optimal sleep duration, being less physically active, and higher sedentary time was associated with higher risk of all-cause and CVD mortality and non-fatal CVD events, regardless of genetic CVD risk.”
Unhealthy Lifestyle, Genetics and Risk of Cardiovascular Disease and Mortality in 76,958 Individuals from the UK Biobank Cohort Study. Nutrients
Who: White British UK Biobank adults aged 40-69 without CVD at baseline and with ≥2 online 24-h dietary assessments
PMID 34959842
other primary study · 2022
“Compared to those in the unhealthy lifestyle category, life expectancy of 45-year-old men in the moderate lifestyle category was 2.1 (95% CI 1.9; 2.3) years longer and in the healthy group 4.4 (95% CI 4.1; 4.7) years longer (Table 3 ).”
Healthy lifestyle in older adults and life expectancy with and without heart failure. Eur J Epidemiol
Who: Men and women aged 45 and older (three subcohorts aged ≥55 or ≥45) in the Rotterdam Study, the Netherlands, free of heart failure at baseline
PMID 35083603
other primary study · 2023
“For all-cause mortality, compared to participants with no or one healthy lifestyle factors, the multivariable adjusted HRs were 0.73 (95% CI 0.61, 0.88) for two factors, 0.70 (95% CI 0.57, 0.86) for three factors, and 0.56 (95% CI 0.37, 0.86) for four factors, p -trend < 0.0001 (Table 2 ; Fig.”
Association of a healthy lifestyle with mortality in older people. BMC Geriatr
Who: Initially healthy community-dwelling Australians aged 70 or older in the ASPREE trial and its ALSOP and ASPREE-XT sub-studies, free of cardiovascular disease, dementia and major disability
PMID 37821846
other primary study · 2024
“Genetic and lifestyle factors were independently associated with lifespan.”
Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies. BMJ Evid Based Med
Who: UK Biobank adults of European ancestry recruited 2006-2010 (lifestyle weights derived from US NHANES 2005-2018, 19,484 adults; PRS from LifeGen GWAS)
PMID 38684374