Which Form?

B12

3.4

Moderate

consensus

Available Forms

  • Methylcobalamin (preferred)
  • cyanocobalamin
  • sublingual or oral

Dosage & Timing

Dosage

  • Individualized based on blood levels and genetic status
  • methylcobalamin form preferred for those with MTHFR variants

Timing

  • With meals
  • part of methylation support stack

Expert Positions

Andrew Huberman
Andrew Huberman
Recommends
Peter Attia
Peter Attia
Recommends
Rhonda Patrick
Rhonda Patrick
Recommends
Bryan Johnson
Bryan Johnson
No Direct Coverage
Mark Hyman
Mark Hyman
Strongly Recommends

What Each Expert Says

Andrew Huberman
Andrew Huberman
Recommends

Discusses B12 in context of mitochondrial function and mental health, noting deficiencies can cause neurological and psychiatric symptoms. References it as critical for brain health alongside folate.

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