Dosage Lookup
Vitamin B12
3.4
Moderate
consensus
Based on expert consensus data from publicly available videos, not medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement.
Consensus Protocol
Dosage
- 1,000 mcg daily of methylcobalamin for general supplementation
- Attia uses B12 alongside methylfolate to target homocysteine below 9
- Hyman recommends testing methylmalonic acid and homocysteine levels to guide dosing — higher doses may be needed for those with malabsorption, MTHFR variants, or on PPIs
Form
- Methylcobalamin (methylated B12) is preferred over cyanocobalamin by all experts who specify a form
- Attia and Patrick both specifically recommend methylcobalamin
- Hyman recommends methylated B-vitamins broadly
- Sublingual or injection forms may be necessary for those with gut absorption issues
Timing
- Take with meals
- Often taken as part of a B-complex or alongside methylfolate for optimal methylation support
- Attia pairs B12 with methylfolate in his daily protocol
Notes
- Test homocysteine and methylmalonic acid (MMA) levels before supplementing — these are more sensitive markers of functional B12 status than serum B12 alone
- Consider genetic testing for MTHFR and FUT2 polymorphisms (Patrick)
- Those on PPIs, metformin, the elderly, vegans, and people with celiac disease or gut issues are at highest risk for deficiency
- B12 is water-soluble, so toxicity risk is very low even at high doses
Expert Positions
What Each Expert Says
Huberman's coverage of B12 is limited and indirect. His most relevant mention comes in a guest episode with Dr. Chris Palmer on metabolic psychiatry, where B12 is discussed alongside folate and iron as critical vitamins for mitochondrial function with direct impact on mental health. Dr. Palmer highlights that deficiencies in these nutrients, particularly in certain populations, are linked to neurological and psychiatric symptoms. B12 is not part of Huberman's frequently discussed foundational supplement stack.
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