Timing Protocol
What researchers say about when, how and with what to take vitamin b12, and how strong the evidence is.
The verdict on Vitamin B12 overall
Leaning for
Vitamin B12 supplements are worth taking.
10 sources: 1 positive, 9 partly
Short answer
Take it with meals, often in a B-complex or with methylfolate for methylation. B12 and methylfolate are taken together daily in one stack (Peter Attia).
No timing claim on Vitamin B12 has been checked yet. The timing notes above are not yet backed by counted mentions.
Built from every credited researcher and cited study on each claim.
Vitamin B12 supplements are worth taking.
Mark Hyman, 5 mentions on this claim
Positive Video
on The Dr. Hyman Show, at 47:29 · positive
“so taking b6 b12 and folate super important for the brain”
on The Dr. Hyman Show, at 27:42 · positive
“you want to take B vitamins particularly the methylation B vitamins we talked about methyl folate methyl B12”
on The Dr. Hyman Show, at 05:53 · positive
“take extra B6 B12 and folate”
on The Dr. Hyman Show, at 09:59 · partly
“zinc iron vitamin D B12 omega-3 fats these are the common deficiencies we see in vegans so you have to take supplements with it”
on The Dr. Hyman Show, at 12:35 · partly
“you take these acid blocking medications and you take b12 it's not going to work you need to be 12 shot”
Researchers
Rahul Jandial, 2 mentions on this claim
Partly Video
on Rangan Chatterjee's channel, at 27:49 · partly
“they can supplement if they're choosing to go vegan”
on Rangan Chatterjee's channel, at 03:48 · partly
“They can supplement if they're choosing to go vegan. They you recommend they supplement with something containing and B vitamins”
Giles Yeo, on The Diary Of A CEO, at 1:09:54
Partly Video · Opinion
Open the tape at 1:09:54 →“you have to supplement when you're on a plant-based diet okay you have to supplement certain things vitamin B12”
Tom Frieden, on The Dr. Hyman Show, at 1:24:58
Partly Video · Opinion
Open the tape at 1:24:58 →“I'm not sure that taking vitamin B12 will help, but it's not going to hurt.”
David Perlmutter, on Rangan Chatterjee's channel, at 55:56
Partly Video · Opinion
Open the tape at 55:56 →“methylated folate uh B12 sublingually and a B complex and every once in a while a B12 shot”
James Greenblatt, on The Dr. Hyman Show, at 09:16
Partly Video · Opinion
Open the tape at 09:16 →“vitamin B12 is a pet peeve of mind because our normal range the lab slips might say 220 to 1100 and nobody feels well with a level of 220”
Dr. E, on The Dr. Hyman Show, at 59:17
Partly Video · Opinion
Open the tape at 59:17 →“if their homosysteine is high check that MTHFR and then you support them with B vitamins”
Dr. Chris Palmer, on Huberman Lab, at 2:16:44
Partly Video · Opinion
Open the tape at 2:16:44 →“if you're going to be a vegan or vegetarian please take appropriate supplement”
Dr. Craig Koniver, on Huberman Lab, at 1:23:22
Partly Video · Opinion
Open the tape at 1:23:22 →“if you're going to take a B vitamin take a methylated B vitamin”
Studies
VITACOG, cited on The Dr. Hyman Show, at 1:10:29
Partly Study
Open the tape at 1:10:29 →“when people had a marker in their blood called homocyine homoyine is high the people that took B complex vitamins B12 folic acid”
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You know when to take Vitamin B12. A free account opens the interaction warnings for your whole stack. Pro adds chat about your own situation, drawn from 3,700+ hours of recorded interviews with 380 researchers and doctors, plus 48,500+ research studies.
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