Growth hormone secretagogue (oral)
MK-677
Ibutamoren
Not approved — strong appetite/cortisol effects
Based on expert consensus from publicly available videos plus public FDA/regulatory status — not medical advice. Peptides are prescription territory; consult a physician before using anything here.
The Verdict
An oral GH secretagogue that reliably spikes appetite and can raise cortisol/prolactin — Huberman and guests flag the side-effect profile. Not a casual longevity tool.
The Evidence
FDA / Legal Status
Not FDA-approved
Human Evidence
Strongly increases hunger; cited established uses are narrow (short stature, burn recovery)
Sport / Doping
Banned in sport
Safety Flags
- Marked hyperphagia (hunger), plus cortisol/prolactin effects
- GH-elevation cancer risk; GH/longevity tension in older adults
Who Covers It
Other experts in the panel had no substantive coverage of this peptide — we don't guess their position.
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