Supplement Stack

The Longevity Supplement Stack: What Holds Up

The short answer

Strip away the hype and the foundation is short: omega-3, creatine, vitamin D and magnesium. The molecules that dominate longevity marketing (NMN, resveratrol, metformin) are where the sources split.

Based on what was said in publicly available videos, not medical advice. Always consult your healthcare provider before starting or changing a supplement.

1. Omega-3 (EPA/DHA)

1-3g combined EPA/DHA daily

with a meal

The base of most longevity stacks. Targets on record: a 12% omega-3 index, and 1.5-3g of EPA a day for mood and the brain.

2. Creatine Monohydrate

3-5g daily

any time, daily

Monohydrate is the form on record, for muscle and more and more for the brain and aging. No loading phase needed.

3. Vitamin D3 (+ K2)

blood-test guided (commonly 2,000+ IU)

with a fat-containing meal

D3 is the form on record, often paired with K2. Dose to a blood level; don't guess.

4. Magnesium (glycinate)

300-500mg elemental daily

evening

About 45-50% of people don't get enough. Glycinate for daily use and sleep (see magnesium glycinate vs citrate).

5. Secondary: Glycine, Zinc

glycine 1-3g / zinc 15-30mg

glycine evening; zinc with food

Glycine for sleep and zinc round out the foundation for most people.

This stack is short on purpose. Its foundation is a few supplements with broad support and a clear safety record: omega-3, creatine, vitamin D and magnesium, plus glycine and zinc. The supplements that dominate longevity marketing are the ones the sources split on, and NR failed the gold-standard ITP mouse trial. A real longevity stack is short, cheap and boring. The biggest levers aren't in a bottle at all: sleep, resistance training and Zone 2 cardio outrank every supplement on this page.

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