Expert Position
Physician focused on longevity and healthspan, host of The Drive
Peter Attia strongly recommends creatine monohydrate and calls elevated creatinine on a blood test a common false alarm — it usually reflects muscle mass, not kidney damage. The dose deep-dive on his show comes from guest Layne Norton, who reports that 5 grams a day and higher doses both produce gains in lean mass and strength.
“they basically showed we take five grams a day you get increases in lean mass and strength and performance you take more than five grams a day you also get increases in lean mass and performance”
Layne Norton, on Peter Attia's show · watch @ 8:51 →
All 4 other experts also take a positive position on Creatine.
A maintenance dose of 5 grams a day is the figure used on his show. Layne Norton, reviewing the meta-analysis on that episode, notes that both 5 grams and higher doses produce gains in lean mass and strength, which makes 5 grams the practical floor rather than a ceiling.
Attia addresses this directly: creatine raises blood creatinine because of muscle mass, and that rise is routinely misread as kidney damage. He points to cystatin C as the measure that is not confounded this way.
No. Loading is optional — it saturates muscle faster but can cause GI irritation — and cycling off is unnecessary for long-term use.