Supplement Comparison

Magnesium Bisglycinate vs Glycinate: Are They the Same Thing?

They're the same compound. 'Bisglycinate' is the chemically precise name (one magnesium bound to two, or 'bis', glycine molecules), and 'glycinate' is the everyday shorthand for exactly the same thing. Any real-world difference comes from the brand, not the word: whether it's fully chelated or cheaply 'buffered' with magnesium oxide, plus fillers and the elemental dose. Any source that recommends 'glycinate' is recommending bisglycinate.

The verdict on Magnesium overall

Strong consensus for

Magnesium supplements are worth taking.

8 sources: 6 positive, 2 partly

8 sources: 6 positive, 2 partly

Based on what researchers say in publicly available videos, not medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement.

What the evidence says about the form

Each claim gets one verdict, worked out from every counted mention. One dot is one source: a researcher or a study. Tap a dot to see its receipt.

positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.

  1. Not enough evidence

    Magnesium glycinate and malate are better absorbed than other forms of magnesium.

    2 sources: 1 positive, 1 partly. Fewer than 3 sources so far.

    Researchers say

    1 positive, 1 partly

    Studies show

    No study counted yet.

    6 more not counted · see why
    We could not confirm who is speaking. 2
    We could not tell where the evidence comes from. 2
    The study cited could not be identified. 1
    A host's remark inside an interview. 1
    Show the receipts from 2 sources
    1. Rhonda Patrick, on The Dr. Hyman Show, at 1:16:02 Video · positive · Opinion

      “magnesium malate magnesium um glycinate and citrate if you're constipated right so so those so those are the organic salts which are more bioavailable”

    2. Mark Hyman Video · partly · 2 mentions

      on The Dr. Hyman Show, at 08:57 · partly · Opinion

      “but it's not absorbed well so you want to get chelated magnesium you want to get magnesium glycinate or citrate”

      on The Dr. Hyman Show, at 09:06 · partly · Opinion

      “it's not absorbed well so you want to get chelated magnesium you want to get magnesium glycinate or citrate”

  2. Leaning for

    Magnesium glycinate or malate is the best form for daily magnesium needs.

    3 sources: 3 partly.

    Researchers say

    3 partly

    Studies show

    No study counted yet.

    7 more not counted · see why
    We could not tell what position it takes on this claim. 3
    We could not confirm who is speaking. 2
    The study cited could not be identified. 1
    A host's remark inside an interview. 1
    Show the receipts from 3 sources
    1. Dr Michael Breus, on Rangan Chatterjee's channel, at 1:28:48 Video · partly · Opinion

      “So, I start most people on magnesium glycinate um with about 150 to 200 milligrams.”

    2. Mark Hyman Video · partly · 3 mentions

      on The Dr. Hyman Show, at 08:59 · partly · Opinion

      “you want to get chelated magnesium you want to get magnesium glycinate or citrate if you tend to be more”

      on The Dr. Hyman Show, at 27:47 · partly · Opinion

      “magnesium glycinate or magnesium 38 which is some the form that crosses the bloodb brain barrier helps reduce anxiety”

      on The Dr. Hyman Show, at 09:30 · partly · Opinion

      “if you take too much magnesium citrate you'll get diarrhea so you want to use magnesium glycinate”

    3. Dr. Rhonda Patrick Video · partly · 2 mentions

      on Huberman Lab, at 21:11 · partly · Opinion

      “I would say malite would be the best. That has to do with the short chain fatty acids being good for the gut.”

      on FoundMyFitness, at 23:09 · neutral · Opinion

      “taking a supplement magnesium glycinate citrate malate are”

Where the sources disagree

Built from every credited researcher and cited study on each claim.

Strong consensus for

Magnesium supplements are worth taking.

Supports it 6 sources
Partly 2 sources
Not enough evidence

Magnesium glycinate and malate are better absorbed than other forms of magnesium.

Supports it 1 source
Partly 1 source

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Key Differences

Chemistry

Magnesium Bisglycinate

Magnesium + two glycine molecules ('bis' = two)

Magnesium Glycinate

Identical — 'glycinate' is shorthand for the same bis-glycine chelate

The Name

Magnesium Bisglycinate

The precise, technical label brands use to sound premium

Magnesium Glycinate

The common everyday label — same product

The Real Variable

Magnesium Bisglycinate

Fully chelated vs 'buffered bisglycinate' (cut with cheap magnesium oxide to lower cost)

Magnesium Glycinate

Same — always check for 'buffered' and read the elemental dose

Absorption

Magnesium Bisglycinate

Well-absorbed, gentle (glycine chelate)

Magnesium Glycinate

Identical

Elemental Magnesium

Magnesium Bisglycinate

Varies by product, not by the name

Magnesium Glycinate

Varies by product, not by the name

What the sources say

Magnesium Bisglycinate

When a source says 'glycinate', it means this compound

Magnesium Glycinate

Named for daily use and sleep

Bottom Line

Save yourself the confusion: magnesium bisglycinate and magnesium glycinate are the same molecule. 'Bis-glycinate' just spells out that two glycine molecules are bound to each magnesium, which is what 'glycinate' has always meant. Marketers use 'bisglycinate' because it sounds more scientific, but the compound is the same. What varies between products is quality: some cheap 'buffered bisglycinate' powders are partly magnesium oxide, which dilutes the well-absorbed chelate you're paying for. So ignore the label word, avoid 'buffered' versions if you want the gentle fully-chelated form, and check the elemental magnesium per serving. Under either name, this is the form named for daily use and sleep.

Protocol notes — Magnesium

Dosage
300-500mg of elemental magnesium daily (Peter Attia: 300-500mg; Rhonda Patrick: ~400mg; Mark Hyman: 400mg+).
Form
Glycinate or malate for everyday absorption (Rhonda Patrick). Carbonate for full absorption without gut effects (Peter Attia). Threonate for the brain only; don't count it toward daily needs. Citrate or oxide if you want a looser bowel.
Timing
Smaller doses spread across the day absorb better. Carbonate in the morning (Peter Attia). An evening dose for sleep.
Notes
Standard blood tests for magnesium are unreliable: the body holds plasma levels steady by drawing from bone, which hides a deficiency (Peter Attia; Rhonda Patrick). Too much supplemental zinc can block magnesium absorption. Physically active adults need 10-20% more than the sedentary RDA.

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