Supplement Comparison

Magnesium Glycinate vs Threonate: Which Form Should You Take?

Take glycinate (or malate) for your daily magnesium needs. Add threonate only if you want targeted cognitive support — but don't count it toward your daily requirement.

The verdict on Magnesium overall

Strong consensus for

Magnesium supplements are worth taking.

8 sources: 6 positive, 2 partly

8 sources: 6 positive, 2 partly

Based on what researchers say in publicly available videos, not medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement.

What the evidence says about the form

Each claim gets one verdict, worked out from every counted mention. One dot is one source: a researcher or a study. Tap a dot to see its receipt.

positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.

  1. Not enough evidence

    Magnesium glycinate and malate are better absorbed than other forms of magnesium.

    2 sources: 1 positive, 1 partly. Fewer than 3 sources so far.

    Researchers say

    1 positive, 1 partly

    Studies show

    No study counted yet.

    6 more not counted · see why
    We could not confirm who is speaking. 2
    We could not tell where the evidence comes from. 2
    The study cited could not be identified. 1
    A host's remark inside an interview. 1
    Show the receipts from 2 sources
    1. Rhonda Patrick, on The Dr. Hyman Show, at 1:16:02 Video · positive · Opinion

      “magnesium malate magnesium um glycinate and citrate if you're constipated right so so those so those are the organic salts which are more bioavailable”

    2. Mark Hyman Video · partly · 2 mentions

      on The Dr. Hyman Show, at 08:57 · partly · Opinion

      “but it's not absorbed well so you want to get chelated magnesium you want to get magnesium glycinate or citrate”

      on The Dr. Hyman Show, at 09:06 · partly · Opinion

      “it's not absorbed well so you want to get chelated magnesium you want to get magnesium glycinate or citrate”

  2. Not enough evidence

    Magnesium glycinate is a better form for sleep than magnesium threonate.

    No counted mention yet.

    Researchers say

    No researcher counted yet.

    Studies show

    No study counted yet.

    3 more not counted · see why
    We could not tell what position it takes on this claim. 2
    A host's remark inside an interview. 1
  3. Leaning for

    Magnesium glycinate or malate is the best form for daily magnesium needs.

    3 sources: 3 partly.

    Researchers say

    3 partly

    Studies show

    No study counted yet.

    7 more not counted · see why
    We could not tell what position it takes on this claim. 3
    We could not confirm who is speaking. 2
    The study cited could not be identified. 1
    A host's remark inside an interview. 1
    Show the receipts from 3 sources
    1. Dr Michael Breus, on Rangan Chatterjee's channel, at 1:28:48 Video · partly · Opinion

      “So, I start most people on magnesium glycinate um with about 150 to 200 milligrams.”

    2. Mark Hyman Video · partly · 3 mentions

      on The Dr. Hyman Show, at 08:59 · partly · Opinion

      “you want to get chelated magnesium you want to get magnesium glycinate or citrate if you tend to be more”

      on The Dr. Hyman Show, at 27:47 · partly · Opinion

      “magnesium glycinate or magnesium 38 which is some the form that crosses the bloodb brain barrier helps reduce anxiety”

      on The Dr. Hyman Show, at 09:30 · partly · Opinion

      “if you take too much magnesium citrate you'll get diarrhea so you want to use magnesium glycinate”

    3. Dr. Rhonda Patrick Video · partly · 2 mentions

      on Huberman Lab, at 21:11 · partly · Opinion

      “I would say malite would be the best. That has to do with the short chain fatty acids being good for the gut.”

      on FoundMyFitness, at 23:09 · neutral · Opinion

      “taking a supplement magnesium glycinate citrate malate are”

Where the sources disagree

Built from every credited researcher and cited study on each claim.

Strong consensus for

Magnesium supplements are worth taking.

Supports it 6 sources
Partly 2 sources
Not enough evidence

Magnesium glycinate and malate are better absorbed than other forms of magnesium.

Supports it 1 source
Partly 1 source

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Key Differences

Elemental Magnesium

Magnesium Glycinate

High — good for meeting daily RDA of 400mg

Magnesium Threonate

Very low: don't count it toward daily needs

Best For

Magnesium Glycinate

Sleep, muscle relaxation, general deficiency, GABA activity

Magnesium Threonate

Cognitive function, memory, brain health specifically

Absorption

Magnesium Glycinate

Well-absorbed, gentle on the stomach

Magnesium Threonate

Crosses blood-brain barrier effectively

GI Side Effects

Magnesium Glycinate

Minimal — better tolerated than citrate or oxide

Magnesium Threonate

Minimal — but very low elemental Mg content

Cost

Magnesium Glycinate

Affordable — widely available

Magnesium Threonate

2-3x more expensive per serving

What the sources say

Magnesium Glycinate

Named as a well-absorbed daily form

Magnesium Threonate

Taken for sleep and the brain, with a caution not to rely on it for daily magnesium

Bottom Line

Glycinate (or malate) is the main magnesium supplement for most people. It delivers meaningful elemental magnesium with good bioavailability and little stomach upset. Threonate has a niche for cognitive support because it crosses the blood-brain barrier, but its elemental magnesium is too low to meet daily needs. Carbonate is where the sources split: it is taken as the best-absorbed form by some and avoided as poorly absorbed by others. The practical move: use glycinate or malate for your 300-500mg daily base, and add threonate only if cognitive support is a goal. Nearly 50% of Americans are magnesium-deficient, so picking the right form matters less than supplementing consistently.

Protocol notes — Magnesium

Dosage
300-500mg of elemental magnesium daily (Peter Attia: 300-500mg; Rhonda Patrick: ~400mg; Mark Hyman: 400mg+).
Form
Glycinate or malate for everyday absorption (Rhonda Patrick). Carbonate for full absorption without gut effects (Peter Attia). Threonate for the brain only; don't count it toward daily needs. Citrate or oxide if you want a looser bowel.
Timing
Smaller doses spread across the day absorb better. Carbonate in the morning (Peter Attia). An evening dose for sleep.
Notes
Standard blood tests for magnesium are unreliable: the body holds plasma levels steady by drawing from bone, which hides a deficiency (Peter Attia; Rhonda Patrick). Too much supplemental zinc can block magnesium absorption. Physically active adults need 10-20% more than the sedentary RDA.

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