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01 · David Sinclair

we're talking about here is is an epigenetic effect. Sure. I mean, anything that is genetic is is essentially irreversible. So, this is an epigenetic effect. What I would imagine is that after you've been gray for many, many years, it's going to be very difficult to reverse that. But in the early phases, when you're getting this spattering of gray and color, gray and color, you are able to get those those packages of DNA back to where they were when you were young, using some of the methods that we're talking about today, and we've talked about in other episodes. And this has to do with those stem cells that produce pigment, the melanocytes. Yep. And these sit right next to our hair shafts. They do, and

▶ 1:42:59 – 1:43:44

02 · Andrew Huberman · guest: Martin Picard

experiment in this. Yeah. >> Um, what's the deal? Can people reverse the graying of their hair by reducing their stress? Can people accelerate the graying of their hair by stressing more? >> Mhm. Uh, likely both are true. Yes. >> Okay. And I think what we discovered is that hair graying at least temporarily is reversible. And this was surprising because it goes against this notion that aging is a linear you know uh process that just happens over time no matter what you do. And here we should know actually a a hallmark of aging which is you know depigmentation losing color in your beard and your hair um is something that happens to almost everyone but at

▶ 1:07:50 – 1:08:35

03 · David Sinclair

of those people's lives where where they they didn't stop working, they didn't they didn't sleep, they didn't go on a vacation. And so I think it's very clear that stress can induce gray hair loss of color from the hair. But what's also remarkable about about that finding is that it proves that gray hair is reversible. Which means that what we're talking about here is is an epigenetic effect. Sure. I mean, anything that is genetic is is essentially irreversible. So, this is an epigenetic effect. These findings suggest that aging is a whole-body process. And one of the most important places that we see that process play out is in the brain, where age-related diseases remain one of the

▶ 1:40:02 – 1:40:47

04 · Bryan Johnson

reverse the gray hair and it's one of our things we're trying to figure out how to do yeah we've got some strategies but I think we've uh yeah we uh we prioritize volume first didn't we volume and density before uh what color yeah then we saw this my my boys being the reference point you can see the lips in here oh yeah my posture right here like this is why this was a contributing factor to my my jugular vein being stenosed is um shocking to see that what terrible