other primary study · 2016
“Only a negligible proportion of the patients were able to achieve consistent weight loss.”
High Adherence to CPAP Treatment Does Not Prevent the Continuation of Weight Gain among Severely Obese OSAS Patients. J Clin Sleep Med
Who: Long-term CPAP users with OSAS at one Finnish pulmonary clinic; mean age 55.6 years, BMI 33.5, AHI 33.7, 24% women
PMID 26888588
other primary study · 2021
“In addition, our study emphasises previous expectations, that weight continues to increase during long-term adherence to CPAP therapy, irrespectively of changes in cravings or exercise habits.”
Mood, sleepiness, and weight gain after three years on CPAP therapy for sleep apnoea. Eur Clin Respir J
Who: Consecutive patients referred to Turku University Hospital with symptoms suggesting OSAS; CPAP users (median BMI 34.7, median AHI 21) versus non-users (median BMI 28.2, median AHI 8.7, including 20 without OSAS)
PMID 33643550
other primary study · 2019
“We observed that 8 weeks of CPAP was associated with increased body weight and fat-free mass.”
Effects of Continuous Positive Airway Pressure on Body Composition in Individuals with Obstructive Sleep Apnea: A Non-Randomized, Matched Before-After Study. J Clin Med
Who: Community-recruited adults aged 18-65 with BMI ≥ 25 kg/m2 and a recent diagnosis of at least mild OSA (AHI ≥ 5), no prior CPAP and no type 2 diabetes; mean BMI 35.2, 42% female
PMID 31405137
controlled trial · 2022
“Commencing CPAP alone did not lead to weight change.”
A 12-month weight loss intervention in adults with obstructive sleep apnoea: is timing important? A step wedge randomised trial. Eur J Clin Nutr
Who: Adults aged 19-68 with BMI above the healthy range and newly diagnosed moderate-severe OSA, recommended CPAP; 75% men, mean age 49.4 years, mean BMI 34.0
PMID 35927505
controlled trial · 2026
“We conclude that CPAP-induced weight gain, probably primarily from increased FFM, occurred without measurable changes in REE, physical activity, or significant increases in reported caloric intake.”
Continuous positive airway pressure effects on energy expenditure, intake, hormonal regulation, and body composition: a randomized trial. Sleep
Who: Chinese adults aged 20 or older with moderate-to-severe OSA (AHI of 15/h or more) at two centers in Taiwan, mostly male (88.5%) and overweight or obese, median age 45.9, BMI below 40
PMID 40874641