Does calorie restriction slow aging? 1 of 1 study agrees

Does calorie restriction slow aging?

The claim checked: In CALERIE, calorie restriction slowed the pace of aging by 2 to 3% Hear it at 35:06

What do the studies say?

Not enough evidence

The one study here is the CALERIE analysis he described. It found restriction cut the pace of aging on DunedinPACE by 2–3% in healthy, non-obese adults.

Computed from 1 study that test this point, each judged by two readers, in full. Fewer than 3 sources so far.

What was said on the podcast?

“And what they found was that the calorierest restricted group that were eating 12% fewer calories than the controls had a decreased pace of aging of 2 to 3%. Which could correspond to a whopping 10 to 15% decrease in all cause mortality risk.”

David Sinclair, Lifespan · Fasting as a Path to Longevity: The Facts | Lifespan with Dr. David Sinclair - S2, Ep. 2 · 35:06 on YouTube
Comes up in 11 episodes of the show.

The point checked Not enough evidence

In CALERIE (~12% restriction achieved), calorie restriction slowed the pace of aging by 2-3% on the DunedinPACE clock

Agree 1

controlled trial · 2023 · landmark · cited on tape

“Standardized treatment effects on DunedinPACE correspond to a reduction in the pace of aging of 2–3%.”

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat Aging
Who: Healthy non-obese US adults (men 21-50, premenopausal women 21-47, BMI 22.0-27.9), mean age 38, 70% women, CALERIE Phase 2 RCT
PMID 37118425

Partly agree 0

None.

Disagree 0

None.

What else was said but not tested?

That 2-3% could correspond to a 10-15% lower all-cause mortality risk

Calorie restriction is the strongest, most reproducible way to extend lifespan in animals (probably humans too)

A second CALERIE analysis (Belsky, KDM biological age) found the CR group aged ~0.11 vs 0.71 biological years per year