A claim you hear on longevity podcasts

Does banana in a blueberry smoothie cancel the polyphenols?

The claim checked: Mixing banana into a blueberry smoothie has been shown to decrease its polyphenols Hear it at 3:24:16

What do the studies say?

Not enough evidence

No study we found tests this point yet.

The study behind the claim tested something else. See what it tested

What was said on the podcast?

“Don't mix the blueberry with the banana smoothie because it it has been shown to decrease the the polyphenols which are important.”
Rhonda Patrick, a guest on Huberman Lab · The Best Vitality & Health Protocols | Dr. Rhonda Patrick · 3:24:16 on YouTube
The study behind the claim The retelling overstates it

What did the study actually test?

She names no study on tape. This is the one human trial that matches her description. Impact of polyphenol oxidase on the bioavailability of flavan-3-ols in fruit smoothies: a controlled, single blinded, cross-over study. Food Funct, 2023. Controlled, single-blinded crossover trial, 8 healthy men.

What was saidWhat the study did
What was given Differs Banana mixed into a blueberry smoothie A banana smoothie and a mixed-berry smoothie, each drunk on its own. No arm mixed banana with berries.
Compared with Differs The same smoothie without banana A flavan-3-ol capsule. The 84% drop is measured against the capsule.
What was measured Differs The berries' polyphenols Blood levels of cocoa flavan-3-ols over 6 hours after one drink.
Where the compound came from Differs Polyphenols from the berries A standardized cocoa extract added to each smoothie.
Who took part Differs Anyone who drinks the smoothie 8 healthy men.

What it found

“In contrast, the intake of the high PPO drink resulted in a Cmax of 96 ± 47 nmol L-1, 84% lower than that obtained after capsule intake.”

PMID 37615673

How the authors extend it

“In conclusion, bioavailability of flavan-3-ols, and most likely other dietary polyphenol bioactives, can be reduced substantially by the co-ingestion of high PPO-containing products, the implications of which are of importance for dietary advice and food preparation both at home and in industrial settings.”

PMID 37615673

Funded by Mars, Inc., which supplied the cocoa extract; 3 of the authors work for Mars. Two readers agreed on the label, and the paper was read in full.

The point checked Not enough evidence

Adding banana to a berry smoothie sharply reduces the polyphenols from the berries.

No study we found tests this point. These were read, and each tests a different question:

  • Uptake and bioavailability of anthocyanins and phenolic acids from grape/blueberry juice and smoothie in vitro and in vivo. Br J Nutr, 2015 · PMID 25778541
  • Colonic availability of polyphenols and D-(-)-quinic acid after apple smoothie consumption. Mol Nutr Food Res, 2011 · PMID 21370449
  • Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery. J Proteome Res, 2015 · PMID 26561314

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