Timing Protocol

When to Take Sleep Optimization

What researchers say about when, how and with what to take sleep optimization, and how strong the evidence is.

The verdict on Sleep Optimization overall

Leaning for

Sleep is the most important pillar of health and longevity.

8 sources: 4 positive, 4 partly

8 sources: 4 positive, 4 partly

Based on what researchers say in publicly available videos, not medical advice. Always consult your healthcare provider before starting, stopping, or changing any supplement.

Short answer

Take sleep supplements 30-60 minutes before bed. Delay caffeine 90-120 minutes after waking (Andrew Huberman). Finish the last meal 3+ hours before bed (Bryan Johnson). Stop drinking liquids around 4 PM for unbroken sleep (Bryan Johnson). Wind down for 30-60 minutes before bed with no screens.

Full Protocol

Timing
Take sleep supplements 30-60 minutes before bed. Delay caffeine 90-120 minutes after waking (Andrew Huberman). Finish the last meal 3+ hours before bed (Bryan Johnson). Stop drinking liquids around 4 PM for unbroken sleep (Bryan Johnson). Wind down for 30-60 minutes before bed with no screens.
Dosage
Magnesium threonate 145mg + Apigenin 50mg + L-theanine 100-400mg (discussed on Huberman Lab). Optional: Glycine 2g, GABA 100mg or Myo-inositol 900mg for waking in the night.
Form
Magnesium threonate or bisglycinate for sleep (threonate crosses the blood-brain barrier). Apigenin comes from chamomile, and theanine is taken as L-theanine. Glycine and valerian root are other options.
Notes
Theanine may cause overly vivid dreams in some people; cut back or stop if it does. Melatonin is generally not advised for healthy adults: it adds only a few minutes of sleep, and store-bought doses are often far above what the body makes (Andrew Huberman). Light, temperature and consistency come before supplements.

What the evidence says about timing

One verdict, worked out from every counted mention. One dot is one source: a researcher or a study. Tap a dot to see its receipt.

positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.

Leaning for

Finishing the last meal 3 or more hours before bed improves sleep.

8 sources: 3 positive, 5 partly.

Researchers say

3 positive, 5 partly

Studies show

No study counted yet.

26 more not counted · see why
Show the receipts from 8 sources
  1. Dr Michael Breus, on Rangan Chatterjee's channel, at 55:36 Video · positive · Opinion

    “But for most people, again, let make sure you check with your doctor. You should probably stop all food three to four hours”

  2. Mark Hyman Video · positive · 2 mentions

    on The Dr. Hyman Show, at 03:41 · positive · Opinion

    “you don't want to eat late three hours before bed”

    on The Dr. Hyman Show, at 09:43 · positive · Opinion

    “don't eat three hours before bed so give yourself three hours before your last meal in bed”

  3. Bryan Johnson Video · positive · 3 mentions

    on Bryan Johnson's channel, at 20:44 · positive · Opinion

    “my resting heart rate is 46 if it's 46 I'm going to have a perfect night sleep”

    on Bryan Johnson's channel, at 09:48 · positive · Opinion

    “finish digesting my food prior to the time I sleep at 8:30 p.m. This dramatically lowers my resting heart rate, which dramatically improves my sleep.”

    on Bryan Johnson's channel, at 03:41 · partly · Opinion

    “trying to avoid big heavy meals at the end of the day that could really be having a negative effect on your sleep”

  4. Rangan Chatterjee Video · partly · 2 mentions

    on Rangan Chatterjee's channel, at 23:19 · positive · Opinion

    “if you are able to stop eating two or ideally even 3 hours before before bed you may find that your sleep quality is improved”

    on Rangan Chatterjee's channel, at 26:13 · partly · Opinion

    “if you can try not to eat for those two to three hours before bed you may find you're sleeping better”

  5. Roger Seheult, on Rangan Chatterjee's channel, at 1:41:38 Video · partly · Opinion

    “usually you want it maybe a good three to four hours um before you go to bed”

  6. Stacy Sims, on The Diary Of A CEO, at 1:33:02 Video · partly · Opinion

    “they don't sleep very well because if you are eating right before bed”

  7. Peter Attia, on The Drive, at 04:41 Video · partly · Opinion

    “how much the sort of low glucose empty stomach um impacted sleep and it was it was profound”

  8. Dr. Marie-Pierre St-Onge, on Huberman Lab, at 38:52 Video · partly · Opinion

    “I personally like to eat my last meal at least three hours before going to bed.”

Where the sources disagree

Built from every credited researcher and cited study on each claim.

Leaning for

Finishing the last meal 3 or more hours before bed improves sleep.

Supports it 3 sources
Partly 5 sources
Leaning for

Sleep is the most important pillar of health and longevity.

Supports it 4 sources
Partly 4 sources

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Timing is half the equation

You know when to take Sleep Optimization. A free account opens the interaction warnings for your whole stack. Pro adds chat about your own situation, drawn from 3,700+ hours of recorded interviews with 380 researchers and doctors, plus 48,500+ research studies.

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