Dosage Lookup
Vitamin C
Moderate
consensus
250-1,000mg daily for general health. Hyman recommends 500-1,000mg for immune support and detoxification. Johnson takes vitamin C alongside iron in his morning stack. Patrick notes that oral doses above 200mg have diminishing returns in plasma levels due to absorption limits. For therapeutic IV use (sepsis, cancer adjunct), much higher doses are administered under medical supervision.
Consensus Protocol
Dosage
- 250-1,000mg daily for general health
- Hyman recommends 500-1,000mg for immune support and detoxification
- Johnson takes vitamin C alongside iron in his morning stack
- Patrick notes that oral doses above 200mg have diminishing returns in plasma levels due to absorption limits
- For therapeutic IV use (sepsis, cancer adjunct), much higher doses are administered under medical supervision
Form
- Ascorbic acid is the most common and well-studied oral form
- Liposomal vitamin C may offer modestly better absorption than standard ascorbic acid
- For skin health, topical L-ascorbic acid serum (stabilized formulation) is recommended by Attia's guests
- IV sodium ascorbate is used for therapeutic applications
Timing
- Can be taken any time of day with or without food
- Johnson takes it in the morning with his supplement stack
- Pair with iron-rich foods or supplements to enhance iron absorption
- Topical vitamin C serum is best applied in the morning before sunscreen for antioxidant protection
Notes
- Most people can obtain adequate vitamin C from a diet rich in citrus fruits, bell peppers, kiwis, strawberries, and leafy greens
- Supplementation is most beneficial for those with inadequate dietary intake, high stress levels, smokers, or those recovering from illness
- Hyman emphasizes whole food sources like kiwis and peppers over synthetic supplements for sleep-related benefits
- Doses above 2,000mg daily may increase kidney stone risk in susceptible individuals
Expert Positions
What Each Expert Says
Huberman covers vitamin C in two main contexts: immune support and skin health. In his colds and flu episode, he notes that high-dose vitamin C has shown limited effectiveness compared to zinc and NAC, which he considers more promising immune supplements. In his skin health episode, he recommends supplementing with vitamin C alongside niacinamide and collagen-rich sources like bone broth as part of nutritional support for healthy, youthful-looking skin. His overall stance is that vitamin C has a role but is not a priority supplement.
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More on Vitamin C
Common Questions
How much Vitamin C should you take?
250-1,000mg daily for general health. Hyman recommends 500-1,000mg for immune support and detoxification. Johnson takes vitamin C alongside iron in his morning stack. Patrick notes that oral doses above 200mg have diminishing returns in plasma levels due to absorption limits. For therapeutic IV use (sepsis, cancer adjunct), much higher doses are administered under medical supervision.
What form of Vitamin C is best?
Ascorbic acid is the most common and well-studied oral form. Liposomal vitamin C may offer modestly better absorption than standard ascorbic acid. For skin health, topical L-ascorbic acid serum (stabilized formulation) is recommended by Attia's guests. IV sodium ascorbate is used for therapeutic applications.
When should you take Vitamin C?
Can be taken any time of day with or without food. Johnson takes it in the morning with his supplement stack. Pair with iron-rich foods or supplements to enhance iron absorption. Topical vitamin C serum is best applied in the morning before sunscreen for antioxidant protection.