Goal-Based Guide
On a GLP-1 drug the priority is holding onto muscle, so creatine and protein matter most here, even though omega-3 has broader support overall. Here's what each one does.
The biggest risk on a GLP-1 drug like Ozempic or Wegovy isn't the fat you lose. It's the muscle: fast weight loss strips lean mass unless you defend it. The supplements below are for holding onto muscle and covering the nutrient gaps of eating far less.
Ranked by the verdict on whether each supplement works, worked out from every counted mention. Each dot is one source: a researcher or a study.
positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.
Creatine is worth taking.
11 sources: 8 positive, 2 partly, 1 neutral
Magnesium supplements are worth taking.
8 sources: 6 positive, 2 partly
Omega-3 supplements are worth taking.
17 sources: 7 positive, 10 partly
Eating more protein than the official recommended amount preserves muscle and supports healthy aging.
16 sources: 5 positive, 11 partly
Electrolyte supplements are worth taking.
8 sources: 3 positive, 5 partly
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The evidence-backed core is protein plus resistance training; the rest covers the gaps of a much smaller appetite:
This page shows you which supplements researchers agree on for glp-1 support. A free account opens the dose, form and timing for each supplement, with the interactions to watch. Pro adds chat answers drawn from 3,700+ hours of recorded interviews with 380 researchers and doctors, plus 48,500+ research studies, each one cited.
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