Best Supplements to Take on GLP-1 Drugs

All 5 experts actively recommend omega-3 supplementation, making this one of the strongest consensus topics. Patrick and Attia provide the deepest mechanistic coverage, Huberman recommends 1-3g EPA for mood and cognition, Hyman lists omega-3 as a foundational supplement everyone needs, and Johnson includes omega-3 sources in his Blueprint diet.

All 5 experts actively recommend creatine — and the consensus has expanded well beyond muscle. Huberman, Attia, and Patrick each feature dedicated deep dives on creatine as brain fuel for cognition under stress, sleep deprivation, and aging — not just strength and hypertrophy. Johnson includes it in his Blueprint stack; Hyman names it one of six essential daily supplements for muscle mass, insulin sensitivity, and brain health as we age. The most common worry — elevated creatinine on bloodwork — is a harmless artifact of muscle metabolism, not kidney damage.

4 of 5 experts actively recommend magnesium supplementation. Patrick and Hyman are the strongest advocates, each discussing it across multiple videos. Attia recommends 300-500mg daily for bone health and personally supplements with three forms. Johnson's Blueprint stack does not explicitly include magnesium.

4 of 5 experts actively recommend more protein than the 0.8 g/kg RDA — converging on roughly 1.2-2 g/kg paired with resistance training (Johnson's coverage is thinner and plant-forward). The 'high protein shortens lifespan' fear traces mainly to guest Valter Longo's low-IGF-1 view; the core experts largely resolve it by noting that exercise redirects IGF-1 toward muscle and that sarcopenia — not mTOR — dominates aging risk after 50.

All 5 experts acknowledge the importance of electrolytes (sodium, potassium, magnesium) for health and performance, but they diverge sharply on sodium intake. Huberman is the strongest advocate for deliberate sodium supplementation, dedicating a full episode to the topic. Attia takes a cautious, clinical approach — he warns that high sodium triggers fructose production and raises blood pressure, while also explaining the critical role of proper hydration with electrolytes. Patrick emphasizes potassium and magnesium from whole foods over sodium supplementation. Johnson uses sodium-free salt substitutes and experienced firsthand electrolyte imbalance during his sauna experiments. Hyman warns that over-drinking plain water without electrolytes is dangerous, but focuses more on reducing processed-food sodium than supplementing it.