Verdict
Strong consensus against
NMN or NR supplements improve longevity.
10 sources: 1 positive, 2 partly, 7 negative
By Arun AgrahriLast reviewed 1 timecoded source
Short answer
Probably not for longevity. No trial shows either extends human life, and NR failed to extend lifespan in the ITP mouse program. Rhonda Patrick warns NMN may accelerate cancer. Andrew Huberman takes both, but for energy, not longevity. Save your money unless you have a specific reason to experiment.
NMN or NR supplements are worth taking.
The verdict on NMN / NAD+ overall. 11 sources: 2 positive, 4 partly, 5 negative
positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.
NMN or NR supplements improve longevity.
10 sources: 1 positive, 2 partly, 7 negative.
Researchers say
1 positive, 1 partly, 6 negative
Mark Hyman, 4 mentions on this claim
Positive Video
on The Dr. Hyman Show, at 27:59 · positive
“I like certain things like nmn which is helped support adad production th000 milligrams a day”
on The Dr. Hyman Show, at 06:38 · positive
“pack in my longevity stack I take and amend about 900 milligrams a day”
on The Dr. Hyman Show, at 32:09 · positive
“to support NAD production again this is really critical for activating longevity switches”
on Huberman Lab, at 2:32:40 · partly
“it's not going to make you live forever or cure every disease, but it's a it's an it's an optimization tool”
Dr. David Sinclair, 4 mentions on this claim
Partly Video
on FoundMyFitness, at 36:40 · partly
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on Lifespan, at 24:55 · partly
“and they do live longer on NMN.”
on Lifespan, at 25:14 · partly
“um but certainly that those mice are healthier and more active and are more youthful”
on The Drive, at 1:31:00 · partly
“we can still extend lifespan using what I know you were this is not gonna tell you we're using the nmn”
Iñigo San-Millán, 2 mentions on this claim
Negative Video
on The Drive, at 2:34:03 · negative
“taking n is that going to increase longevity I don't think so”
on The Drive, at 02:19 · negative
“taking nad is that going to increase longevity i don't think so that's my opinion”
Eric Verdin, on The Drive, at 1:49:10
Negative Video · Opinion
Open the tape at 1:49:10 →“you're not going to solve the problem”
Peter Attia, on The Drive, at 28:29
Negative Video · Opinion
Open the tape at 28:29 →“I kind of think this NAD stuff is noise at the moment”
Richard Miller, 2 mentions on this claim
Negative Video
on The Drive, at 1:51:49 · negative
“did not extend life span in our mice”
on The Drive, at 2:04:01 · negative
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Andrew Huberman, on Huberman Lab, at 08:42
Negative Video · Opinion
Open the tape at 08:42 →“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
Michael Murray, on The Dr. Hyman Show, at 27:21
Negative Video · Opinion
Open the tape at 27:21 →“we're filling that bucket up continually by taking nmn instead of fixing that hole”
Studies show
1 partly, 1 negative
2 cited on tape, not yet checked against the paper
Leonard Guarente, cited on The Dr. Hyman Show, at 35:21
Partly Study
Open the tape at 35:21 →“that's actually one of the first studies if not the first that says that there's some positive benefits in people”
Josh Rabinowitz, cited on The Drive, at 00:48
Negative Study
Open the tape at 00:48 →“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching the companies”
Mark Hyman Video · positive · 4 mentions
on The Dr. Hyman Show, at 27:59 · positive · Opinion
“I like certain things like nmn which is helped support adad production th000 milligrams a day”
on The Dr. Hyman Show, at 06:38 · positive · Opinion
“pack in my longevity stack I take and amend about 900 milligrams a day”
on The Dr. Hyman Show, at 32:09 · positive · Opinion
“to support NAD production again this is really critical for activating longevity switches”
on Huberman Lab, at 2:32:40 · partly · Opinion
“it's not going to make you live forever or cure every disease, but it's a it's an it's an optimization tool”
Dr. David Sinclair Video · partly · 4 mentions
on FoundMyFitness, at 36:40 · partly · Opinion
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on Lifespan, at 24:55 · partly · Their own research
“and they do live longer on NMN.”
on Lifespan, at 25:14 · partly · Their own research
“um but certainly that those mice are healthier and more active and are more youthful”
on The Drive, at 1:31:00 · partly · Their own research
“we can still extend lifespan using what I know you were this is not gonna tell you we're using the nmn”
Leonard Guarente, cited on The Dr. Hyman Show, at 35:21 Study · partly
“that's actually one of the first studies if not the first that says that there's some positive benefits in people”
Iñigo San-Millán Video · negative · 2 mentions
on The Drive, at 2:34:03 · negative · Opinion
“taking n is that going to increase longevity I don't think so”
on The Drive, at 02:19 · negative · Opinion
“taking nad is that going to increase longevity i don't think so that's my opinion”
Eric Verdin, on The Drive, at 1:49:10 Video · negative · Opinion
“you're not going to solve the problem”
Peter Attia, on The Drive, at 28:29 Video · negative · Opinion
“I kind of think this NAD stuff is noise at the moment”
Richard Miller Video · negative · 2 mentions
on The Drive, at 1:51:49 · negative · Their own research
“did not extend life span in our mice”
on The Drive, at 2:04:01 · negative · Their own research
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Andrew Huberman, on Huberman Lab, at 08:42 Video · negative · Opinion
“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
Michael Murray, on The Dr. Hyman Show, at 27:21 Video · negative · Opinion
“we're filling that bucket up continually by taking nmn instead of fixing that hole”
Josh Rabinowitz, cited on The Drive, at 00:48 Study · negative
“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching the companies”
NMN or NR supplements improve longevity.
Mark Hyman, 4 mentions on this claim
Positive Video
on The Dr. Hyman Show, at 27:59 · positive
“I like certain things like nmn which is helped support adad production th000 milligrams a day”
on The Dr. Hyman Show, at 06:38 · positive
“pack in my longevity stack I take and amend about 900 milligrams a day”
on The Dr. Hyman Show, at 32:09 · positive
“to support NAD production again this is really critical for activating longevity switches”
on Huberman Lab, at 2:32:40 · partly
“it's not going to make you live forever or cure every disease, but it's a it's an it's an optimization tool”
Researchers
Dr. David Sinclair, 4 mentions on this claim
Partly Video
on FoundMyFitness, at 36:40 · partly
“If we're exercising, we're taking NAD boosters, we do slow that process down, I believe.”
on Lifespan, at 24:55 · partly
“and they do live longer on NMN.”
on Lifespan, at 25:14 · partly
“um but certainly that those mice are healthier and more active and are more youthful”
on The Drive, at 1:31:00 · partly
“we can still extend lifespan using what I know you were this is not gonna tell you we're using the nmn”
Studies
Leonard Guarente, cited on The Dr. Hyman Show, at 35:21
Partly Study
Open the tape at 35:21 →“that's actually one of the first studies if not the first that says that there's some positive benefits in people”
Researchers
Iñigo San-Millán, 2 mentions on this claim
Negative Video
on The Drive, at 2:34:03 · negative
“taking n is that going to increase longevity I don't think so”
on The Drive, at 02:19 · negative
“taking nad is that going to increase longevity i don't think so that's my opinion”
Eric Verdin, on The Drive, at 1:49:10
Negative Video · Opinion
Open the tape at 1:49:10 →“you're not going to solve the problem”
Peter Attia, on The Drive, at 28:29
Negative Video · Opinion
Open the tape at 28:29 →“I kind of think this NAD stuff is noise at the moment”
Richard Miller, 2 mentions on this claim
Negative Video
on The Drive, at 1:51:49 · negative
“did not extend life span in our mice”
on The Drive, at 2:04:01 · negative
“we tested it and it didn't didn't work um that is it didn't extend Mouse lifespan”
Andrew Huberman, on Huberman Lab, at 08:42
Negative Video · Opinion
Open the tape at 08:42 →“I take 500 milligrams of NR. I also and have separately taken an NMN supplement. I take sublingual NMN. So I'll take anywhere from 1 to 2 grams of NMN as a sublingual powder”
Michael Murray, on The Dr. Hyman Show, at 27:21
Negative Video · Opinion
Open the tape at 27:21 →“we're filling that bucket up continually by taking nmn instead of fixing that hole”
Studies
Josh Rabinowitz, cited on The Drive, at 00:48
Negative Study
Open the tape at 00:48 →“I am completely unconvinced that taking supplemental and R or even nmn by mouth is doing anything other than enriching the companies”
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NMN or NR supplements are not shown to improve longevity. Peter Attia classifies NAD+ boosters as "noise" on his evidence scale, citing the Interventions Testing Program's failure to extend lifespan with NR. Rhonda Patrick warns NMN may accelerate cancer, and notes both precursors break down into nicotinamide, which can block sirtuins, the enzymes they are meant to help.
Andrew Huberman, on his own show, takes NR (500mg) and NMN (1-2g) daily but is open that it's for subjective energy, not proven longevity. Bryan Johnson does not discuss either on the record, so read his position as unstated rather than opposed.
Mark Hyman is the advocate, and his show has hosted guests recommending 1000mg of NMN. Exercise and fasting raise NAD+ on their own and come first.
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