Verdict
Not enough evidence
1,000 to 2,000 mg of EPA a day eases depression.
1 source: 1 positive
By Arun AgrahriLast reviewed
Short answer
Yes. 1,000-2,000mg of EPA a day is the dose on the record, and Andrew Huberman says the trials put it on par with antidepressants. EPA lowers the inflammation that blocks serotonin release. Omega-3 also appears on lists of evidence-based interventions for depression.
Omega-3 supplements are worth taking.
The verdict on Omega-3 overall. 17 sources: 7 positive, 10 partly
positive partly neutral negative Each researcher and each study counts once per claim, however often they come up.
1,000 to 2,000 mg of EPA a day eases depression.
1 source: 1 positive. Fewer than 3 sources so far.
Researchers say
1 positive
Andrew Huberman, on Huberman Lab, at 1:09:49
Positive Video · Opinion
Open the tape at 1:09:49 →“I notice a pretty substantial positive effect of taking anywhere from 1000 milligrams to 2000 milligrams of EPA per day.”
Studies show
No study counted yet.
Andrew Huberman, on Huberman Lab, at 1:09:49 Video · positive · Opinion
“I notice a pretty substantial positive effect of taking anywhere from 1000 milligrams to 2000 milligrams of EPA per day.”
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Claims from podcasts on this question, checked against the studies that test them.
Of 10 studies that test it, 6 partly agree, 3 agree and 1 disagrees.
Of 10 studies that test it, 5 agree, 2 partly agree and 3 disagree.
1,000 to 2,000 mg of EPA a day eases depression. EPA is the part that matters for mood, and the evidence behind it is strong. Andrew Huberman, on his own show, recommends that dose and says the trials he cites put it on par with antidepressants.
EPA lowers the inflammation that blocks serotonin release, and DHA builds the serotonin receptor and keeps it working. Run low on omega-3 and that signaling weakens, which can feed psychiatric disorders.
Mark Hyman counts omega-3 among seven evidence-based moves for depression. The others include elimination diets, thyroid and vitamin D checks, and B vitamins.
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